Abstract: SA-PO668
Assessment of Kidney Size in African American Children with Sickle Cell Disease: A Matched-Pair Analysis
Session Information
- Pediatric Nephrology - 2
October 26, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pediatric Nephrology
- 1900 Pediatric Nephrology
Authors
- Shaoba, Asma B S, SUNY Downstate Health Sciences University, New York City, New York, United States
- Zhang, Yaoping, SUNY Downstate Health Sciences University, New York City, New York, United States
- Gruessner, Angelika C., SUNY Downstate Health Sciences University, New York City, New York, United States
- Nnaji, Okwudili, SUNY Downstate Health Sciences University, New York City, New York, United States
- Mongia, Anil K., SUNY Downstate Health Sciences University, New York City, New York, United States
- Bamgbola, Oluwatoyin F., SUNY Downstate Health Sciences University, New York City, New York, United States
Background
Sickle cell disease (SCD) is caused by a beta-globin gene mutation that produces sickling of red blood cells. Increase in cardiac output from sickle cell anemia produces hyperfiltration that results in a progressive increase in renal size. We aim to examine the impact of SCD morbidity on kidney size using renal ultrasound.
Methods
The study included 31 African Americans with SCD aged 3 to 20 years and 57 matched controls who were seen in outpatient clinic from 01/ 2018 to 12/2022. Cases were matched with controls at 1:2 ratio. We examined the impact of the severity of hemoglobinopathy on kidney size by stratification of subjects based on HBSS and HBSC subtypes, and SCD morbidity score.
Results
Four subjects had HBSC and 27 had HBSS genotypes. The right and the left kidney volume of SCD cases were significantly larger than of controls [p < 0.0001] (Table 1). There was a significant difference in eGFR between subjects and controls, and among individuals with HBSS and HBSC genotypes (Table 1 and Fig. 1). A unit increase in SCD morbidity score was associated with 5.7 and 5.1 cm3 volume increase for right and left kidneys respectively.
Conclusion
Severity of sickle cell anemia positively correlates with a greater eGFR and (therefore) volume of hyperfiltration, which in turn, are the primary determinants of nephromegaly.
Fig 1: Box plot of eGFRs for the difference between matched subjects by hemoglobin genotypes.