Kidney Week

Abstract: SA-PO339

Cardiac Implantable Electronic Device Infections in Patients with Renal Insufficiency: A Meta-Analysis

Session Information

• Hypertension, CVD, and the Kidneys: Clinical Research
  October 26, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Hypertension and CVD

• 1602 Hypertension and CVD: Clinical

Authors

• Chandramohan, Deepak, The University of Alabama at Birmingham, Birmingham, Alabama, United States

Deepak Chandramohan, MD, FASN

• Simhadri, Prathap, AdventHealth, Altamonte Springs, Florida, United States

Prathap Simhadri, MD, MPH, FASN

• Singh, Prabhat, Christus Spohn Health System, Corpus Christi, Texas, United States

Prabhat Singh, MD

• Garapati, Hari Naga, Baptist Medical Center East, Montgomery, Alabama, United States

Hari Naga Garapati, MD, MPH

• Konda, Raghunandan, The University of Alabama at Birmingham, Birmingham, Alabama, United States

Raghunandan Konda, MBBS, MD

• Chandramohan, Divya, The University of Texas at San Antonio, San Antonio, Texas, United States

Divya Chandramohan, MD

• Jena, Nihar K., Trinity Health Oakland Hospital, Pontiac, Michigan, United States

Nihar K. Jena, MD

• Naik, Roopa, Geisinger Health, Danville, Pennsylvania, United States

Roopa Naik, MD

Background

Renal insufficiency is a risk factor for cardiac implantable electronic device (CIED) infection.

Methods

To identify studies, we conducted a comprehensive search of multiple electronic databases. Using the random effects model, we calculated the pooled rates and odds ratios. We utilized the Cochran Q and I2 statistics to detect heterogeneity.

Results

A total of 17 studies comprising 263,819 chronic kidney disease (CKD) and 89,617 end stage renal disease (ESRD) patients were included. The mean age was 68.6 years (95% CI: 66.4-70.8; I2: 99.7). The pooled rate of CIED infection in patients with CKD was 4.3% (95% CI: 2-8.8; I2: 95.7) and ESRD was 5.9% (95% CI: 3.3-10.5; I2: 99.3). The pooled risk of CIED infection in the CKD population was OR 2.5 (95% CI: 1.9-3.3; p <0.001; I2: 21.1), and in ESRD was OR 2.4 (95% CI: 1.01-5.7; p = 0.046; I2: 88.8). ESRD was associated with higher mortality, OR 2.5 (95% CI: 1.4-4.4.8; p = 0.001; I2: 95).

Conclusion

The rates of CIED infections in renal insufficiency are significant. CKD and ESRD are associated with an increased risk of infection. ESRD patients have an increased risk of mortality.