Abstract: TH-PO1034
Association between Weight Change and Estimated Glomerular Filtration Rate Decline in a Middle-Aged Population
Session Information
- CKD: Epidemiology, Risk Factors, and Prevention - 1
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Deravi, Niloofar, Shahid Beheshti University of Medical Sciences Research Institute for Endocrine Sciences, Tehran, Tehran, Iran (the Islamic Republic of)
- Ramezankhani, Azra, Shahid Beheshti University of Medical Sciences Research Institute for Endocrine Sciences, Tehran, Tehran, Iran (the Islamic Republic of)
- Rahmanian, Mohammad, Shahid Beheshti University of Medical Sciences Research Institute for Endocrine Sciences, Tehran, Tehran, Iran (the Islamic Republic of)
- Hadaegh, Parto, Shahid Beheshti University of Medical Sciences Research Institute for Endocrine Sciences, Tehran, Tehran, Iran (the Islamic Republic of)
- Esteghamati, Alireza, Tehran University of Medical Sciences, Tehran, Tehran, Iran (the Islamic Republic of)
- Azizi, Fereidoun, Shahid Beheshti University of Medical Sciences Research Institute for Endocrine Sciences, Tehran, Tehran, Iran (the Islamic Republic of)
- Hadaegh, Farzad, Shahid Beheshti University of Medical Sciences Research Institute for Endocrine Sciences, Tehran, Tehran, Iran (the Islamic Republic of)
Background
Little is known about the impact of weight change on the estimated glomerular filtration rate (eGFR) decline. We examined the association between weight changes and eGFR decline risk among middle-aged Iranians, participating in the Tehran Lipid and Glucose Study cohort.
Methods
A total of 4,748 individuals aged ≥30 years were selected. We defined weight change as difference in body weight during 3 years. The outcome was an eGFR decline of ≥30% and ≥40%. Cox regression models were utilized to calculate multivariable hazard ratios (HRs, 95% confidence interval (CI)) for different body weight changes (>10% weight loss; 5% to 10% weight loss; -5% to 5% weight change (reference group); 5% to10% weight gain; >10% weight gain).
Results
After a median follow-up of 9.4 years, there were 498 and 144 cases of eGFR decline of ≥30% and ≥40%, respectively. Individuals with a weight gain of ≥10% had a 71% higher risk (1.71, 1.15-2.55) for eGFR decline of ≥30%; the comparable value for eGFR decline of ≥40% was 2.85 (1.46-5.57). Those with a 5%-10% weight loss had higher risk for eGFR decline of ≥30% [(1.30 (0.98-1.72), P=0.06]; and an 86% (1.86, 1.18-2.93) higher risk for ≥40% eGFR decline. The impact of weight gain was more prominent among hypertensive individuals for eGFR decline of ≥30% (P for interaction=0.007). In a sensitivity analysis, among those with eGFR>60 ml/min per 1.73 m2 and without eGFR decline during weight change period, weight gain of >10% was associated with a 53% higher risk of eGFR decline ≥30% (1.53 (0.99-2.37).
Conclusion
Among the middle-aged Iranian population, there was significant association between both weight gain and weight loss with subsequent eGFR decline. Our results underscore the clinical importance of monitoring weight as a factor in renal risk assessment.
Incidence rates and hazard ratios (95% CI) for eGFR decline (A.≥30% and B.≥40%) according to the weight change categories