Kidney Week

Abstract: TH-PO1038

Association of Water Intake with Incident CKD in the UK Biobank Study

Session Information

• CKD: Epidemiology, Risk Factors, and Prevention - 1
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Kim, Hyung Woo, Yonsei University College of Medicine, Seoul, Korea (the Republic of)

Hyung Woo Kim, MD

• Heo, Ga Young, Yonsei University College of Medicine, Seoul, Korea (the Republic of)

Ga Young Heo, MD

• Park, Cheol Ho, Yonsei University College of Medicine, Seoul, Korea (the Republic of)

Cheol Ho Park, MD, PhD

• Park, Jung Tak, Yonsei University College of Medicine, Seoul, Korea (the Republic of)

Jung Tak Park, MD, PhD

• Han, Seung Hyeok, Yonsei University College of Medicine, Seoul, Korea (the Republic of)

Seung Hyeok Han, MD, PhD

• Yoo, Tae-Hyun, Yonsei University College of Medicine, Seoul, Korea (the Republic of)

Tae-Hyun Yoo, MD, PhD

• Kang, Shin-Wook, Yonsei University College of Medicine, Seoul, Korea (the Republic of)

Shin-Wook Kang, MD, PhD

Background

Water intake has been suggested as a preventive strategy for chronic kidney disease (CKD). Nevertheless, there is a lack of evidence to suggest that higher water intake may be beneficial in the prevention of CKD.

Methods

This prospective, population-based cohort study enrolled participants without a history of CKD from the UK Biobank. Participants with heart failure, valvular heart disease, or a history of diuretic use were excluded. The main exposure was total daily fluid intake including water, tea, and coffee. Inverse probability of treatment weighting (IPTW) based on propensity scores was used to build groups with different amount of daily fluid intake. The primary outcome was the newly diagnosed CKD and the risks were estimated by Cox regression models.

Results

Among 286,139 participants (median age, 57 years; men, 48.2%; median estimated glomerular filtration rate, 97.9 ml/min/1.73 m²), 6,816 (2.4%) cases of incident CKD occurred. Participants were categorized into five groups according to the amount of daily fluid intake: <1.5 L/d (n=117,555), 1.5 to 2.0 L/d (n=87,613), 2.0 to 2.5 L/d (n=48,845), 2.5 to 3.0 L/d (n=19,026), and ≥3.0 L/d (n=13,100). Compared with participants who intake 1.5 to 2.0 L/d of fluid, the respective hazard ratios (95% confidence intervals) for those with <1.5 L/d, 2.0 to 2.5 L/d, 2.5 to 3.0 L/d, and ≥3.0 L/d were 1.06 (1.01-1.13), 1.06 (0.98-1.14), 1.04 (0.93-1.16), and 1.26 (1.11-1.43), respectively.

Conclusion

The relationship between fluid intake and the development of CKD appears to be non-linear. The findings of this study indicate that consuming a high volume of fluid may not be associated with a reduced risk of incident CKD.