Abstract: TH-PO989
Association of Zinc Deficiency with Abdominal Fat and Muscle Mass Areas in Patients on Hemodialysis
Session Information
- Physical Activity and Lifestyle in Kidney Diseases
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Ishida, Junko, Kinjo Gakuin University, Nagoya, AICHI, Japan
- Muramoto, Nao, Kinjo Gakuin University, Nagoya, AICHI, Japan
- Tanaka, Masako, Kinjo Gakuin University, Nagoya, AICHI, Japan
- Yamada, Yoshiteru, Taiseikai Medical Corporation, Ogaki, GIFU, Japan
- Yamada, Mayumi, Taiseikai Medical Corporation, Ogaki, GIFU, Japan
- Asano, Ai, Taiseikai Medical Corporation, Ogaki, GIFU, Japan
- Matsuoka, Teppei, Taiseikai Medical Corporation, Ogaki, GIFU, Japan
- Kato, Akihiko, Hamamatsu University Hospital, Hamamatsu, SHIZUOKA, Japan
Background
Zinc (Zn) deficiency is highly prevalent in hemodialysis (HD) patients. However, the relationship between Zn deficiency and body muscle and fat masses remains to be clarified in HD patients. So, we aimed this study to examine the relationship between serum Zn levels and anthropometric parameters in HD patients in a cross-sectional design.
Methods
We measured abdominal muscle area (AMA), subcutaneous fat area (ASFA) and visceral fat area (AVFA) on transverse slice of computed tomography (CT) at L3 to L4 of vertebral bodies in 287 patients who had been undergoing regular HD for more than 2 years (median age: 69.0 years old, M/F = 200/87, diabetes (DM)/non-DM = 87/200). We adjusted these parameters by height square. This study was approved by the Institutional Ethics Committee of Kinjo Gakuin University and supported by JSPS KAKENHI(JP20K10391).
Results
Serum Zn was lower than the reference range (80~130 μg/dL) in almost of the patients (97%). Median Zn level was significantly lower in non-DM patients (56.0 [51.0-62.0] μg/dL) when compared with DM patients (58.0 [53.0-66.0] μg/dL) (p<0.05). Zn deficiency (<60 μg/dL) was found in 64.5% of non-DM patients and 54.0% of DM patients, respectively.
AMA, ASFA, AVFA were significantly lower in non-DM than in DM patients (p<0.05) (Table). There was a significant and positive correlation between serum Zn and AMA in non-DM patients (r=0.185, p<0.01), but not in DM patients. Serum Zn was also significantly and negatively correlated with ASFA, but not with AVFA in DM and non-DM groups. Multiple regression analyses revealed that serum Zn was a significant determinant of AMA and ASFA.
Conclusion
Our findings suggested that Zn deficiency is associated with abdominal muscle wasting, while with accumulation of subcutaneous fat mass in non-DM HD patients.
Abdominal anthropometric parameters in non-DM and DM patients
| Primary disease | Non-DM | DM | P value |
| N | 200 | 87 | |
| Age (years) | 70.0 (59.0 - 78.0) | 68.0 (55.0-73.0) | N.S. |
| HD vintage (years) | 10.6 (4.9 - 19.7) | 5.9 (2.9-9.0) | < 0.05 |
| AMA (cm2/m2) | 33.09 (27.66 - 39.23) | 35.31 (30.11 - 41.54) | < 0.05 |
| ASFA (cm2/m2) | 35.17 (22.09 - 56.14) | 43.60 (32.40 - 61.19) | < 0.01 |
| AVFA (cm2/m2) | 51.33 (37.59 - 70.29) | 64.24 (42.73 - 87.99) | < 0.01 |
Mann Whitney U test. All variables were expressed as the median and interquartile range (25th to 75th percentiles).
Funding
- Other NIH Support