Abstract: TH-PO162
Clinical Implications of Radiopharmaceutical Uptake in the Skull as a New Marker of CKD-MBD: Findings of Bone Scintigraphy
Session Information
- CKD-MBD: Clinical
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Bone and Mineral Metabolism
- 502 Bone and Mineral Metabolism: Clinical
Authors
- Kim, Keunyoung, Pusan National University School of Medicine, Busan, Korea (the Republic of)
- Song, Sang Heon, Pusan National University School of Medicine, Busan, Korea (the Republic of)
Background
The aim of this study is to evaluate the potential role of radiopharmaceutical uptake in skull using bone scintigraphy as a new objective maker for CKD-MBD.
Methods
We retrospectively reviewed 122 CKD patients (M:F, 70:52) who were evaluated with bone scintigraphy. The control of 195 subjects (M:F, 66:129) who have no evidence of disease state of the breast cancer for female and the prostate cancer for male were also recruited. The quantitative indices were defined as the radiopharmaceutical uptake in skull and the ratio of the skull to the ilium (SIR). The bone mineral density (BMD) values and trabecular bone score (TBS) were acquired from dual energy X-ray absoroptiometry (DXA).
Results
In all enrolled CKD patients, median TBS showed deteriorated state compared with control group. The SIR had negatively correlation with DXA values; lumbar spine (r =-0.309, P<0.001); femoral neck (r=-0.262, P<0.001), total femur (r =-0.264, P<0.001) and TBS (r=-0.251, P<0.001). SIR and TBS were remained as the independent variables showed significant correlation with levels of parathyroid hormone, calcium and creatinine in CKD patients using multiple regression.
Conclusion
The SIR was significant for the assessment of metabolic status of CKD-MBD and may therefore potentially be used as an objective tool for the assessment of bone health in CKD patients.
Figure 1. Quantitative Analysis of Bone scan
Figure 2. Representative results from the analysis
A. All values from DXA were significantly lower in the CKD patients compared with the control group.
B. The radioactivity counts in the skull was significantly higher in the CKD patients.
C. The normalized value of SIR showed exaggerated the difference between CKD and control.