Abstract: TH-PO931
Concentric vs. Eccentric Cycling: Effects of Progressive Training in Older Patients with CKD: A Randomized Trial
Session Information
- Geriatric Nephrology: Innovations and Insights
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Geriatric Nephrology
- 1300 Geriatric Nephrology
Authors
- Sun, Chien Yao, National Cheng Kung University, Tainan, tainan, Taiwan
- Chao, Chia-Ter, National Taiwan University Hospital, Taipei, Taiwan
- Chang, Yu Tzu, National Cheng Kung University, Tainan, tainan, Taiwan
Background
Sarcopenia is common in CKD patients and leads to negative clinical outcomes. Eccentric cycling, which involves muscle lengthening under load, offers benefits like lower energy cost and perceived exertion, enabling higher intensity training. This study evaluates the effectiveness of a novel eccentric cycling (ECCcyc) intervention to reverse sarcopenia in older CKD patients.
Methods
Patients over 55 years with confirmed CKD were randomized into three groups: ECCcyc exercise, concentric cycling (CONcyc), or exercise education control. They completed 24 sessions over eight weeks, three times per week, for 20-30 minutes each on a stationary bike. Training was at RPE 13, starting at 50% of maximal cardiopulmonary output, with weekly increases of 5-10%. Efficacy (body composition, performance, cardiopulmonary fitness) was assessed at baseline and after intervention using the GEE statistical method.
Results
Thirty-one CKD patients were assigned to ECCcyc (11), CONcyc (10), and control (10) groups. Post-24 sessions, significant improvements were seen in the ECCcyc group in physical function, cardiopulmonary capacity, and quality of life. Skeletal muscle percentage increased by 3.4% in ECCcyc, while CONcyc and control groups declined by 4.4% and 4.1%, respectively (group-time interaction P<0.001). Knee strength rose from 26.2 to 30.1 kg (+14.9%) in ECCcyc, compared to 22.5 to 24.3 kg (+8.0%) in CONcyc, and decreased from 23.6 to 23.5 kg (-0.4%) in the control group. Peak oxygen consumption increased by 16.8% in ECCcyc and 15.7% in CONcyc, but decreased by 11.2% in the control group (P<0.001). The 6-minute walking distance increased by 6.5% in ECCcyc, 10.7% in CONcyc, and 3.8% in the control group (P<0.001).
Conclusion
This study provides promising evidence for the feasibility of a novel cycling modality to reverse sarcopenia in older CKD patients.
Effects of different exercise modalities on physical outcomes in older CKD patients (between-group by time interaction analyzed using the Generalized Estimating Equations method).
Funding
- Other NIH Support