Kidney Week

Abstract: TH-PO452

Association between Age and Body Mass Index in Patients with End-Stage Autosomal Dominant Polycystic Kidney Disease (ADPKD) in the United States and Japan

Session Information

• Cystic Kidney Diseases: Clinical Assessment and Therapeutic Directions
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Genetic Diseases of the Kidneys

• 1201 Genetic Diseases of the Kidneys: Cystic

Authors

• Suwabe, Tatsuya, Toranomon Byoin, Minato-ku, Tokyo, Japan

Tatsuya Suwabe, MD, MS, PhD

• Torres, Vicente E., Mayo Clinic Minnesota, Rochester, Minnesota, United States

Vicente E. Torres, MD, PhD

• Vaughan, Lisa E., Mayo Clinic Minnesota, Rochester, Minnesota, United States

Lisa E. Vaughan, MS

• Madsen, Charles D., Mayo Clinic Minnesota, Rochester, Minnesota, United States

Charles D. Madsen

• Harris, Peter C., Mayo Clinic Minnesota, Rochester, Minnesota, United States

Peter C. Harris, PhD

• Hoshino, Junichi, Juntendo Daigaku, Bunkyo-ku, Tokyo, Japan

Junichi Hoshino, MD, PhD, MPH

• Nishio, Saori, Hokkaido Daigaku, Sapporo, Hokkaido, Japan

Saori Nishio, MD, PhD

Background

Dietary interventions have been proposed to delay the progression of ADPKD. Body mass index (BMI) has been associated with ADPKD progression. However, the long-term effects of dietary interventions and BMI have not been proven.

Methods

Cross-sectional analysis using data from the United States Renal Data System (USRDS) and the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) to compare the ages and their relation to BMI and other clinical characteristics at initiation of renal replacement therapy (RRT) in these two populations, and their possible association with different dietary habits.

Results

The study included 3,556 patients (1,877 men and 1,679 women; mean age 58.1±13.1 years) who initiated RRT in 2006 and 2007 from the USRDS (2,491) and JRDR (1,065). The mean ages at initiation of RRT were 56.6±13.1 years in the United States and 61.6±12.5 years in Japan (p<0.0001). BMI was 28.2±7.1 kg/m2 in the USRDS and 22.0±3.3 kg/m2 in the JRDR (p<0.0001). Japanese participants were the oldest at time of RRT, followed in descending order by Asian Americans, White Americans, and African Americans. Japanese participants also had the lowest BMI, followed in ascending order by Asian Americans, White Americans, and African Americans. Univariable and multivariable analyses showed that BMI was significantly and inversely associated with age at initiation of RRT in the entire cohort, as well as separately in both the American and Japanese participants. Estimated GFR was not associated with age at initiation of RRT overall and in the USRDS populations, and was significantly, but positively correlated in the JRDR population. As expected, comorbidities were associated with age at initiation of RRT.

Conclusion

BMI is significantly associated with age at initiation of RRT in patients with ADPKD in both the United States and Japan. Japanese had lower BMI and were older than US people of various ethnicities at the initiation of RRT. The lower-calorie diets consumed in Japan are likely associated with lower BMI and a slower progression of ADPKD.

Funding

• NIDDK Support