Kidney Week

Abstract: TH-PO470

Correlation of Total Kidney Volume (TKV), Total Liver Volume (TLV), and Combined TKV and TLV with Abdominal Symptoms in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Session Information

• Cystic Kidney Diseases: Clinical Assessment and Therapeutic Directions
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Genetic Diseases of the Kidneys

• 1201 Genetic Diseases of the Kidneys: Cystic

Authors

• Miranda Cam, Mauricio Alejandro, University Health Network, Toronto, Ontario, Canada

Mauricio Alejandro Miranda Cam, MD

• Dehkharghanian, Taher, University Health Network, Toronto, Ontario, Canada

Taher Dehkharghanian, MD, MSc

• Khowaja, Saima, University Health Network, Toronto, Ontario, Canada

Saima Khowaja

• Song, Xuewen, University Health Network, Toronto, Ontario, Canada

Xuewen Song, PhD

• Sarie, Yasmina, University Health Network, Toronto, Ontario, Canada

Yasmina Sarie

• Khalili, Korosh, University Health Network, Toronto, Ontario, Canada

Korosh Khalili, MD

• Kline, Timothy L., Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States

Timothy L. Kline, MS, PhD

• Pei, York, University Health Network, Toronto, Ontario, Canada

York Pei, MD, FASN

Background

Mass effect (e.g. early satiety, flank pain, abdominal distention and pain) symptoms from polycystic kidney and liver enlargement can result in clinically significant symptoms and complications, and negatively impact the quality of life in patients with ADPKD. Several studies have documented a significant correlation of these symptoms with TKV or TLV. Here we report a single center correlative study of mass effect symptoms with TKV, TLV, and combined TKV+TLV

Methods

Prospective study at the Center of Innovative Management in PKD in Toronto between October 2017-July 2021. All study patients had a clinical diagnosis of ADPKD based on kidney imaging, underwent a research protocol for detailed clinical and laboratory data, genetic testing and MRI measurements of height-adjusted (ht-) TKV, TLV, and combined TKV+TLV. Volume measures were divided by quintiles (Q). Mass-effect symptoms were assessed using a standardized research questionnaire and by review of their medical records

Results

The study cohort comprises 250 patients, with a mean age of 46 years and 56.4% female. Their median htTLV, htTKV, and htTKLV were 1182, 702, and 1884 ml/m, respectively. We found that Q4-Q5 discriminate patients with mobility limitation by all volumetric groups whereas Q5 discriminates the severity of abdominal distention and abdominal pain by htTLV and htTKLV (Figure 1). The lower bound of Q5 in htTKV, htTLV, and htTKLV were 1009, 1337, 2323 ml/m, respectively

Conclusion

Our study suggest specific thresholds that correlate with clinically important “mass effect” symptoms (i.e. mobility limitation, severity of abdominal distention and pain). Multivariate analysis will be performed to further delineate the effects of age, sex, and cystic organ volumetric with “mass effect” symptoms

Funding

• Government Support – Non-U.S.