Kidney Week

Abstract: TH-PO733

Pain Interference and Social Participation among Kidney Transplant Recipients

Session Information

• Transplantation: Clinical - 1
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Transplantation

• 2102 Transplantation: Clinical

Authors

• Pucci, Maria G., Multi-Organ Transplant Program, University Health Network and University of Toronto, Toronto, Ontario, Canada

Maria G. Pucci

• Cochrane, Sambea, Multi-Organ Transplant Program, University Health Network and University of Toronto, Toronto, Ontario, Canada

Sambea Cochrane

• Farragher, Janine, Department of Occupational Science and Occupational Therapy, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Janine Farragher, PhD

• Bartlett, Susan J., Centre for Outcomes Research and Evaluation, McGill University Health Centre, Montreal, Quebec, Canada

Susan J. Bartlett, PhD

• Howell, Doris, Princess Margaret Cancer Research Institute, Toronto, Ontario, Canada

Doris Howell, PhD, RN

• Li, Madeline, Psychosocial Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Madeline Li

• Peipert, John D., Department of Medical Social Sciences, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States

John D. Peipert, PhD

• Mucsi, Istvan, Multi-Organ Transplant Program, University Health Network and University of Toronto, Toronto, Ontario, Canada

Istvan Mucsi, MD, PhD, FASN

Background

Bodily pain can be linked to poor quality of life (QOL) and limited social participation. Social participation, defined as the ability to perform one’s usual social roles and activities, is a patient-valued QOL domain often restricted in kidney transplant recipients (KTRs). Our objective was to explore the association between pain interference (PI) and social participation (SP) among KTRs.

Methods

We analyzed cross-sectional data from a convenience sample of adult KTRs at Toronto General Hospital. PI and SP were assessed using Patient-Reported Outcome Measurement Information System (PROMIS) computer adaptive testing (CAT). We defined moderate/severe PI as a T-score > 60 and low SP as a T-score < 45. We used Spearman correlation analysis to explore the relationship between SP and PI and employed multivariable linear and logistic regression to further examine the association, after adjusting for covariables (age, sex, marital status, racialized status, comorbidity, hemoglobin, albumin, eGFR, months since transplant, depression, and fatigue). Multiple imputation was used to address missing data.

Results

The mean (SD) age of the 282 participants was 52 (14) years, 62% were male, 59% were white. The median (IQR) months since transplant was 37 (120). The mean (SD) SP and PI scores were 52 (9) and 50 (10), respectively. A moderate negative correlation existed between SP and PI (rho= -0.55, p<0.001). This association remained significant in multivariable linear regression analysis after adjusting for covariables (ß= -.253, p<0.001; 95% CI: -.340 – -.165). Participants with moderate/severe PI were more likely to report low SP compared to those with no or mild PI in multivariable logistic regression analysis after adjusting for covariables (OR= 5.16, p= 0.001; 95% CI: 1.93 – 13.8).

Conclusion

KTRs experiencing significant PI reported more limited SP than those with low PI. Future studies should assess the impact of pain and pain management on social health following transplantation.

Funding

• Private Foundation Support