Kidney Week

Abstract: FR-PO368

Cardiovascular Morbidity Patterns in Patients on Dialysis Globally in Apollo Dial DB

Session Information

• Hypertension, CVD, and the Kidneys: Epidemiology
  October 25, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Hypertension and CVD

• 1602 Hypertension and CVD: Clinical

Authors

• Alejos, Belen, Fresenius Medical Care, Bad Homburg, Hessen, Germany

Belen Alejos, PhD

• Croft, Kaitlyn Renee, Fresenius Medical Care, Bad Homburg, Hessen, Germany

Kaitlyn Renee Croft, MSc

• Jiao, Yue, Fresenius Medical Care, Waltham, Massachusetts, United States

Yue Jiao, PhD

• Wolf, Melanie, Fresenius Medical Care, Bad Homburg, Hessen, Germany

Melanie Wolf

• Carioni, Paola, Fresenius Medical Care, Crema, Italy

Paola Carioni

• Soni, Mitesh, Fresenius Medical Care, Waltham, Massachusetts, United States

Mitesh Soni

• Winter, Anke, Fresenius Medical Care, Bad Homburg, Hessen, Germany

Anke Winter, MD

• Neri, Luca, Fresenius Medical Care, Crema, Italy

Luca Neri, MD, PhD

• Chaudhuri, Sheetal, Fresenius Medical Care, Waltham, Massachusetts, United States

Sheetal Chaudhuri, PhD

• Singh, Kanti, Fresenius Medical Care, Waltham, Massachusetts, United States

Kanti Singh

• Stuard, Stefano, Fresenius Medical Care, Crema, Italy

Stefano Stuard, MD, PhD

• Nikam, Milind, Fresenius Medical Care, Singapore, Singapore

Milind Nikam, MD, MBBS

• Guinsburg, Adrian M., Fresenius Medical Care, Buenos Aires, Argentina

Adrian M. Guinsburg, MD

• Chatoth, Dinesh K., Fresenius Medical Care, Waltham, Massachusetts, United States

Dinesh K. Chatoth, MD, FASN

• Hymes, Jeffrey L., Fresenius Medical Care, Waltham, Massachusetts, United States

Jeffrey L. Hymes, MD

• Koulechov, Kirill, Fresenius Medical Care, Bad Homburg, Hessen, Germany

Kirill Koulechov, PhD

• Usvyat, Len A., Fresenius Medical Care, Waltham, Massachusetts, United States

Len A. Usvyat, PhD

• Larkin, John W., Fresenius Medical Care, Waltham, Massachusetts, United States

John W. Larkin, PhD

• Maddux, Franklin W., Fresenius Medical Care AG, Bad Homburg, Hessen, Germany

Franklin W. Maddux, MD

Background

Cardiovascular diseases (CVDs) affect most people with kidney failure but are undefined globally. We aimed to analyze CVD prevalence among dialysis patients treated in 40 countries across six continents, as represented in the first version of a global dialysis database (Apollo Dial DB).

Methods

Apollo Dial DB includes adult dialysis patient data from a global kidney network during Jan 2018-Mar 2021 (Fresenius Medical Care, Bad Homburg, DE). Data anonymization was performed in alignment with recommendations from a re-identification risk determination (Privacy Analytics, Ontario, CA). This analysis assessed CVD comorbidities based on ICD-10 codes.

Results

Among 543,169 patients included, 79% reported ≥1 CVD condition. The prevalence of CVD conditions showed some differences by age and sex (Figure 1). Hypertension was the most common, affecting 73.6% of patients. Atherosclerotic heart disease affected 19.0%, increasing with age (9.9% in 18-44 years to 24.1% in ≥75) and more common in males (20.3%) than females (17.2%). Congestive heart failure affected 17.5%, also increasing with age. Other conditions included peripheral vascular disease (11.5%), cardiomyopathy (7.3%), and cardiac dysrhythmias (7.1%), all more prevalent in older age groups and slightly higher in males.

Conclusion

Hypertension is the most common CVD comorbidity among dialysis patients globally, followed by atherosclerotic heart disease and congestive heart failure. The prevalence of these conditions increases with age and is slightly higher in males. Future analyses are needed to explore differences by world region, which could inform region-specific management strategies.

Figure 1: Distribution of cardiovascular diseases by age group and gender

Funding

• Commercial Support – Fresenius Medical Care