Abstract: FR-PO394
Etiology of Kidney Failure across the World in MONitoring Dialysis Outcomes (MONDO) Dataset
Session Information
- Hemodialysis Epidemiology and Outcomes
October 25, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Rigodon, Vladimir, Pontificia Universidade Catolica do Parana, Curitiba, PR, Brazil
- Jiao, Yue, Fresenius Medical Care, Waltham, Massachusetts, United States
- Guedes, Murilo Henrique, Pontificia Universidade Catolica do Parana, Curitiba, PR, Brazil
- Tiv, Sophanny, University of Calgary, Calgary, Alberta, Canada
- Peters, Vincent, Catharina Ziekenhuis, Eindhoven, Netherlands
- Wolf, Melanie, Fresenius Medical Care, Bad Homburg, Germany
- Croft, Kaitlyn Renee, Fresenius Medical Care, Bad Homburg, Germany
- Carioni, Paola, Fresenius Medical Care, Crema, Italy
- Winter, Anke, Fresenius Medical Care, Bad Homburg, Germany
- Neri, Luca, Fresenius Medical Care, Crema, Italy
- Chaudhuri, Sheetal, Fresenius Medical Care, Waltham, Massachusetts, United States
- Nikam, Milind, Fresenius Medical Care, Singapore, Singapore
- Toffelmire, Edwin B., Queen's University, Kingston, Ontario, Canada
- Konings, Constantijn, Tilburg University, Tilburg, Netherlands
- Stuard, Stefano, Fresenius Medical Care, Crema, Italy
- Hussein, Rasha Hassan, University of Khartoum, Khartoum, Khartoum, Sudan
- Guinsburg, Adrian M., Fresenius Medical Care, Buenos Aires, Argentina
- Pecoits-Filho, Roberto, Pontificia Universidade Catolica do Parana, Curitiba, PR, Brazil
- Moraes, Thyago Proença de, Pontificia Universidade Catolica do Parana, Curitiba, PR, Brazil
- Raimann, Jochen G., Renal Research Institute, New York, New York, United States
- Ye, Xiaoling, Renal Research Institute, New York, New York, United States
- Larkin, John W., Fresenius Medical Care, Waltham, Massachusetts, United States
- Kotanko, Peter, Renal Research Institute, New York, New York, United States
Group or Team Name
- MONDO Investigators.
Background
MONDO initiative is an academic-industry partnership where providers contribute anonymized data to a shared research dataset. We characterized etiology of kidney failure (KF) from the MONDO 2019 cohort from 41 countries over 20 years.
Methods
Nine institutions contributed longitudinal data to MONDO 2019 (Jan2000-Dec2019). Data anonymization was performed in alignment with recommendations from a re-identification risk determination (Privacy Analytics, Ontario, CA).
Results
MONDO 2019 represents 289,531 patients, of which 170,910 (59.0%) had a known etiology for KF (Figure 1). Worldwide, diabetes (DM) was the leading cause of KF (15.8%), followed by hypertensive diseases (HTD, 14.0%) and glomerular diseases (GD,13.9%). Although DM was the leading cause of KF in North America (NA, 35.1%) and Asia-Pacific (AP, 24.2%), GD was the most common cause of KF in Europe-Middle East-Africa (EMEA, 14.9%) and South America (SA, 16.5%). DM was the second leading cause of KF in EMEA (13.4%) and the third leading cause of KF in SA (12.7%). Other regional differences were observed and included HTD being a more common cause of KF in NA (25.3%) and AP (19.4%) than in SA (14.9%) and EMEA (10.6%).
Conclusion
MONDO 2019 dataset shows that the etiology of KF may vary among world regions and warrants further confirmatory investigations, particularly for glomerular disorders associated with DM. These observations are consistent with findings from registries in US and Europe (Stel VS, et al., NDT 2024).
Funding
- Commercial Support – Fresenius Medical Care