Kidney Week

Abstract: TH-PO870

Racial Disparities in Adverse Cardiovascular and Cerebrovascular Events among Patients with Renal Cell Carcinoma

Session Information

• Race, Ethnicity, and Gender in Kidney Health and Care
  October 24, 2024 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Diversity and Equity in Kidney Health

• 900 Diversity and Equity in Kidney Health

Authors

• Mansoor, Sobia, Landmark Medical Center, Woonsocket, Rhode Island, United States

Sobia Mansoor, MD, MBBS

• Uttam Chandani, Kanishka, Landmark Medical Center, Woonsocket, Rhode Island, United States

Kanishka Uttam Chandani, MD

• Agrawal, Siddharth Pravin, Landmark Medical Center, Woonsocket, Rhode Island, United States

Siddharth Pravin Agrawal, MD

• Bhargava, Sahil, Smt NHL Municipal Medical College, Ahmedabad, Gujarat, India

Sahil Bhargava

• Raval, Maharshi, Landmark Medical Center, Woonsocket, Rhode Island, United States

Maharshi Raval, MD

• Siddiq, Sajid, Landmark Medical Center, Woonsocket, Rhode Island, United States

Sajid Siddiq, MD

• Nadeem, Ahmed, Landmark Medical Center, Woonsocket, Rhode Island, United States

Ahmed Nadeem, MD

• Monsour, Michael J., Landmark Medical Center, Woonsocket, Rhode Island, United States

Michael J. Monsour, MD

Background

Renal cell carcinoma (RCC) is the most prevalent urogenital malignancy and the 13th leading cause of cancer-related mortality. Treatment advances, including ICIs, have improved overall survival (OS). We aim to study racial disparities in major cardiovascular and cerebrovascular events (MACCE) among RCC patients.

Methods

ICD-10 codes were used to identify RCC patients from the NIS 2016–2020 database. MACCE included all-cause in-hospital mortality (ACIHM), acute myocardial infarction (AMI), atrial fibrillation (AF), cerebral events, and sudden cardiac death (SCD). Baseline characteristics and MACCE were compared using chi-square for categorical or ANOVA for continuous data (statistical significance determined p-value<0.05), with results stratified by patient’s race.

Results

434,260 patients were identified: 71.65% (311,100) White, 12.19% (52,950) Black, 10.23% (44,445) Hispanic, 2.25% (9,785) Asian/Pacific Islander, 0.74% (3,215) Native American, and 2.93% (12,765) were of other races. When compared to White patients, ACIHM and SCD were significantly higher in Black patients with an adjusted odds ratio (aOR) of 1.13 (95% CI 1.01-1.26, p=0.025) and Hispanics (aOR of 1.17, 95% CI 1.04-1.33, p=0.01). Cerebral events were higher in Black patients (aOR of 1.35, 95%CI 1.23-1.49, p<0.001) and lower in Hispanics (aOR 0.87, 95%CI 0.77-0.98, p=0.03). Most racial groups were noted to have lower aORs of AF as compared to white patients.

Conclusion

The study noted that cerebral events were higher in black patients, and ACIHM and SCD were considerably higher in black and Hispanic patients. The findings underscore the need for equitable access to healthcare and further research regarding the epigenomic factors involved.