ASN represents more than 21,000 kidney health professionals working to help people with kidney diseases and their families. Comprised of all of ASN's focus areas, the ASN Alliance for Kidney Health allows the society to continue its growth and work towards the goal of a world without kidney diseases.
The latest Nephrology Self-Assessment Program (nephSAP) issue, Volume 23: Issue 4 (Oct 2024): Chronic Kidney Disease is now available online.
RE: primary Membranous nephropathy and HBV infection 51 minutes ago
I would wait several moths after successful therapy of HBV with Entecavir . Follow anti-PLA2R antibody levels, there is a fairly good chance for a ...
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RE: Tip variant FSGS 58 minutes ago
What is the serum albumin level? No indication for repeat kidney biopsy. You might want to consider RTX for relapsing steroid sensitive MCD/FSGS. ...
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RE: IgA With ANCA Positivity 1 hour ago
Do you have EM to further characterize the S1 lesion-e.g. - is a diffuse Podocytopathy present. If so, oral systemic steroids are indicted, in my o...
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RE: APOL-1 mediated kidney disease 1 hour ago
Amplitude Study by Vertex pharma. Multinational study. Sure they are recruiting in your area. ------------------------------ Anurag Tikaria MD, ...
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Pregnancy in Transplant patients with aHUs and on complement inhibitors 2 hours ago
Good Afternoon, I looking to hear some experiences any of you have had in transplant patients who have a dx of aHUS and want to become pregnant....
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IgA With ANCA Positivity 3 hours ago
I have a 50-year-old male with past medical history of hypertension, obesity and prediabetes. Non smoker. Only on Lovaza and amlodipine as meds. Cr...
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RE: Tip variant FSGS 4 hours ago
I did not mean to re biopsy but wait until >1gm to treat with CNI ------------------------------ Kevin Mitchell MD Nephrologist St. Luke?s Medica...
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RE: primary Membranous nephropathy and HBV infection 5 hours ago
I would like to update regarding my patient with MN PLAR2Ab + ve and active HBV infectio . we started him on entecavir 2 months back and HBV DNA is...
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RE: Tip variant FSGS 5 hours ago
I would be hesitant to biopsy to convince mother, nor do I think doing it at a relapse would impact management. What has worked for me (sometimes) ...
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RE: FSGS Tip Variant 5 hours ago
This appeared in related content, so I thought to update community on outcome. Re-initiated Pred 1mg/kg to which he responded in 8 weeks, at which ...
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RE: candiduria after starting cephalexin while already on empagliflozin 25 mg qd for months 6 hours ago
Her 2-year Kidney Failure Risk Equation score is 9%, her 5-year score is 25%. She has time on her side for risk of progression. I would consider ce...
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RE: Renal Biopsy Post Plex 7 hours ago
We typically will use FFP for PLEX if the patient is undergoing a procedure or biopsy. Octoplas should be fine since it is used for acquired defici...
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RE: candiduria after starting cephalexin while already on empagliflozin 25 mg qd for months 7 hours ago
Such "disrespect" (haha) for aldactone! Actually, there is a lot of clinical evidence that it reliably reduces both urine protein and BP in diabeti...
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RE: Anti Gbm Case 8 hours ago
Hi prof what it they don’t have pulmonary symptoms or pulmonary haemorrhage . Can you treat in view of preventing occurrence of pulmonary haemorrha...
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Tip variant FSGS 8 hours ago
18 Y M who I treated tip variant FSGS with a longer steroid taper at the age of 16. Previous biopsy showed no tubulointerstial fibrosis also withou...
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RE: candiduria after starting cephalexin while already on empagliflozin 25 mg qd for months 11 hours ago
Does the rash occurred after antibiotic initiation? As I massively use finerenone in DKD patients and didn’t encountered this AE. I have a practic...
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RE: candiduria after starting cephalexin while already on empagliflozin 25 mg qd for months 16 hours ago
Good point! If no harms are done why not give it a try. ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (949) 388-8885 -...
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RE: Anti Gbm Case 19 hours ago
If a patient with anti-GBM disease has 100% glomerular crescent, oliguria and dialysis dependence, we still treat with PLEX if DAH is present and a...
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RE: candiduria after starting cephalexin while already on empagliflozin 25 mg qd for months 20 hours ago
@Richard Glassock You have me there at spironolactone. There is no good clinical evidence only experimental evidence that it would be useful in ...
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RE: Anti Gbm Case 21 hours ago
C3 normal. Will send echo , blood cultures , cryo and repeat ds dna, Ana. Not behaving in septic manner tho. If patient has anti gbm with renal ...
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RE: KFRE 21 hours ago
Thanks prof glassock --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------
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RE: Renal Biopsy Post Plex 21 hours ago
Thanks prof --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------
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RE: Case 21 hours ago
Thanks dr Rodby thought like you. Patient also not keen on biopsy --------------------------------- Muhammad Soobadar MBChB UK ----------------...
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RE: membranous GN with advanced CKD-treatment plan 1 day ago
Thank u dr Glassock --------------------------------- Alaa Nabih Abdalla nephrology fellow Egypt ---------------------------------
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RE: C3G case 1 day ago
Many thanks for these suggestions. I think tgat a search for concealed monoclonal Ig deposits is warranted in this case. I am very skeptical of a d...
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RE: IgA nephropathy with serum ANCA positivite ( ANA is negative) with no proteinuria 1 day ago
None of these medications are associated with crescent formation in glomeruli, as far as I know. ------------------------------ Richard Glassock ...
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RE: membranous GN with advanced CKD-treatment plan 1 day ago
Yes. Glomerular hypercellularity is not seen in MN even when active in situ formation of sub-epithelial IC is occurring. Recently formation of in s...
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RE: candiduria after starting cephalexin while already on empagliflozin 25 mg qd for months 1 day ago
I agree with local anti-fungal therapy and teaching better genital hygiene, with temporary withholding of Flozins.. I am a little more skeptical of...
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RE: candiduria after starting cephalexin while already on empagliflozin 25 mg qd for months 1 day ago
Re the candiduria it is very much likely that she has vaginal candidiasis which has shown up in the urine culture. Vaginal cotrimazole cream may be...
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RE: membranous GN with advanced CKD-treatment plan 1 day ago
Can intra -membranous deposits . . indicate active in situ formation of IC although there is no endocapilary hypercellularity or any other active l...
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RE: IgA nephropathy with serum ANCA positivite ( ANA is negative) with no proteinuria 1 day ago
Thank you for your input. He is ANA negative. No crescents in biopsy and no proteinuria. I sent repeat ANCA and MPO which is pending currently. -...
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RE: IgA nephropathy with serum ANCA positivite ( ANA is negative) with no proteinuria 1 day ago
Medications : ASA, Atorvastatin, Levothyroxine, Vit D, Coreg and Cozaar. Cozaar started recently. ------------------------------ Radhika Thalla M...
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RE: C3G case 1 day ago
Your pathologist can probably get pronase from you molecular lab. They would routinely use either pronase or proteinase K for DNA extractions. This...
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RE: C3G case 1 day ago
Thank you both dear Dr. @Richard Glassock and @Awais Nauman for your reply and clarification. ------------------------------ Rowan Zyada MSc Egy...
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RE: Drug induced ANCA disease or IgA with crescents? 1 day ago
My reckless brain wonders how "Hydralazine" or "Similarly accused meds" can induce antibody production towards histones -/+ MPO & turn the place in...
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RE: IgA nephropathy with serum ANCA positivite ( ANA is negative) with no proteinuria 1 day ago
Recent studies have shown that ANCA positivity in IgA N is seen in about 2% of patients abd tge clinical feature are similar with or without AbCA e...
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RE: IgA nephropathy with serum ANCA positivite ( ANA is negative) with no proteinuria 1 day ago
What is the full list of medications taken. The anti-MPO antibody might be drug induced. Probably of no consequence, no proteinuria, no indication ...
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IgA nephropathy with serum ANCA positivite ( ANA is negative) with no proteinuria 1 day ago
I have a 74 year old Male with only h/o HTN presented with AKI. Baseline creatinine in October 2023 is 1.2. He had physicals in Aug'24 and showed c...
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RE: candiduria after starting cephalexin while already on empagliflozin 25 mg qd for months 1 day ago
It's a judgment, but personally, I agree with aldactone here. True, there's no long term RCT looking at hard outcomes, but we do know it predictabl...
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RE: candiduria after starting cephalexin while already on empagliflozin 25 mg qd for months 2 days ago
The data on Spironolactone to slow progression of CKD in T2DM is really a mixed bag. Finerenone has a better track record. With obesity . I would p...
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RE: candiduria after starting cephalexin while already on empagliflozin 25 mg qd for months 2 days ago
Thank you.Her home blood pressure today was 142/92 and she has already stopped using hydralazine because of hives. She has difficulty tolerating ev...
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RE: Drug induced ANCA disease or IgA with crescents? 2 days ago
I would not discount the role of Hydralazine as the mist likely cause of the ANCA vasculitis. ------------------------------ Richard Glassock MD,...
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RE: membranous GN with advanced CKD-treatment plan 2 days ago
The very thick GBM may provide an partial explanation for the progressive loss of GFR. The EM describes intra -membranous deposits . Were these dep...
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RE: membranous GN with advanced CKD-treatment plan 2 days ago
Very unusual case. Progression of MN with proteinuria of this magnitude is seldom seen. Was a Congo Red stain performed . Any fibrillar deposits in...
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RE: C3G case 2 days ago
The use of IHC on paraffin sections, without Pronase digestion for epitope retreival, raises issues concerning the true diagnosis as concealed mono...
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RE: C3G case 2 days ago
This patient has a slow smoldering disease. She had symptoms for a year, 2/3rd of gloms are globally or segmentally sclerosed. This degree of chron...
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membranous GN with advanced CKD-treatment plan 2 days ago
65 yo Cocausian male, history of biopsy proven idiopathic membranous nephropathy in 2014, treated with Cyclophophamide and steroids with very good ...
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RE: Eosinophilic infiltrates in a transplant recipient 2 days ago
So pleased that measurement of dd-cfDNA was helpful in your case . I do beleive molecular diagnostics can be useful in selected cases. ----------...
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RE: C3G case 2 days ago
IHC on paraffin secrion, no pronase digestion was done. Pronase digestion is not available here. ------------------------------ Rowan Zyada MSc...
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RE: C3G case 2 days ago
This may be resolving Infection related GN with c3 takes more time to resolve than immunoglobulin IHC on paraffin after pronase digestion will hel...
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