Basic/Clinical Science Session
Large Genomic and Multi-Omic Datasets to Inform Kidney Biology and Diseases
October 25, 2024 | 02:00 PM - 04:00 PM
Location: Room 2, Convention Center
Session Description
Improved computational tools, availability of large medical biobanks, cohorts from clinical diagnostic laboratories, and longitudinal collection of phenotype-specific cohorts have yielded unprecedented power to both detect new causes or risk factors for kidney diseases. This session highlights exemplars leading to unexpected phenotypes, genes, and genetic risk that contribute to pathology.
Learning Objective(s)
- Summarize studies that combine the use genetic information with other omics data to understand kidney diseases
- Discuss the use of medical biobanks in genetic studies
- Define phenotype expansion in the context of established genetic kidney diseases
- Explain the derivation and uses of polygenic risk scores
Learning Pathway(s)
- Genetic Diseases and Development
Moderators
Presentations
- Use of a Clinical Exome Sequencing Database to Identify New Kidney Disease Genes
02:00 PM - 02:30 PM
- Genetic Studies of Paired Metabolomes Reveal Processes at the Interface of Plasma and Urine
02:30 PM - 03:00 PM
- Proteomics Integrated with Genomics in 138,000 Individuals Identify Putative Novel Drug Targets for CKD
03:00 PM - 03:30 PM
- Polygenic Risk Alters the Penetrance of Monogenic Kidney Diseases
03:30 PM - 04:00 PM