Clinical Practice Session
Revisiting "Middle Molecules": Blast from the Past
October 25, 2024 | 02:00 PM - 04:00 PM
Location: Room 6C/F, Convention Center
Session Description
The "middle molecule" hypothesis, formulated in the 1980s, proposed that uremic solutes with molecular weight range of 500 to 2,000 dalton caused toxicity, particularly peripheral neuropathy. The molecular weight range of this group of uremic solutes has since evolved to include large solutes such as beta-2 microglobulin and free light chains. This session reviews the group of large solutes as uremic toxins; behavior of these solutes during hemodialysis, hemodiafiltration, and peritoneal dialysis; and clinical effects of increasing the removal of large solutes.
Learning Objective(s)
- Summarize the history and presumed uremic toxicity of large solutes
- Describe the kinetic behavior of large solutes during hemodiafiltration and hemodialysis
- Describe the removal of large solutes by peritoneal dialysis
- Discuss the clinical effects of increasing the removal of large solutes
Learning Pathway(s)
- Dialysis
Moderators
Presentations
- From Middle Molecules to Large Solutes: A History
02:00 PM - 02:30 PM
- Removal of Large Solutes by Hemodiafiltration vs. Hemodialysis
02:30 PM - 03:00 PM
- How Well Does Peritoneal Dialysis Remove Large Solutes?
03:00 PM - 03:30 PM
- Clinical Effects of Increasing Large Solute Removal
03:30 PM - 04:00 PM