Kidney Week

Translational Session

APOL1-Mediated Kidney Disease: Year in Review, Including the Michelle P. Winn, MD, Endowed Lectureship

October 25, 2024 | 02:00 PM - 04:00 PM

Location: Ballroom 20D, Convention Center

Session Description

More than 10 years ago, variants in the APOL1 gene were identified as a major genetic risk factor for CKD in persons of African ancestry. This session reviews the epidemiology of APOL1-mediated kidney disease (AMKD), the effects of genetic variants on disease progression in native and transplanted kidneys, identification of disease modifiers, and pharmacologic and nonpharmacologic strategies to slow the rate of disease progression.

ASN gratefully acknowledges Duke University School of Medicine, the school’s Division of Nephrology, and several individuals for support of the Winn Endowed Lectureship.

Learning Objective(s)

• Explain the relationship between proteinuria and disease progression in AMKD
• Discuss genetic and environmental disease modifiers for AMKD
• Describe effects of nutrition on disease progression in AMKD
• Identify new therapeutic targets for AMKD

Learning Pathway(s)

• Genetic Diseases and Development
• Glomerular Diseases

Moderators

• Opeyemi A. Olabisi, MD, PhD
• Andreia Watanabe, MD, PhD

Presentations

• APOL1-Mediated Kidney Disease: Variably Proteinuric, Yet Invariably Progressive: The Michelle P. Winn, MD, Endowed Lectureship
  02:00 PM - 02:30 PM
  
  • Kirk N. Campbell, MD, FASN

APOL1-Mediated Kidney Disease: Variably Proteinuric, Yet Invariably Progressive: The Michelle P. Winn, MD, Endowed Lectureship

October 25, 2024 | 02:00 PM - 02:30 PM

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• Genetic and Environmental Modifiers of APOL1-Mediated Kidney Disease: All in the Genes?
  02:30 PM - 03:00 PM
  
  • Simone Sanna-Cherchi, MD

Genetic and Environmental Modifiers of APOL1-Mediated Kidney Disease: All in the Genes?

October 25, 2024 | 02:30 PM - 03:00 PM

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• Can We Eat Our Way out of APOL1-Mediated Kidney Disease? Impact of Nutrition on Disease Progression
  03:00 PM - 03:30 PM
  
  • Titilayo O. Ilori, MD, MS, MSc

Can We Eat Our Way out of APOL1-Mediated Kidney Disease? Impact of Nutrition on Disease Progression

October 25, 2024 | 03:00 PM - 03:30 PM

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• New Targets for Pharmacologic Therapy in APOL1-Mediated Kidney Disease
  03:30 PM - 04:00 PM
  
  • David Friedman, MD

New Targets for Pharmacologic Therapy in APOL1-Mediated Kidney Disease

October 25, 2024 | 03:30 PM - 04:00 PM

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