Kidney Week

Abstract: SA-PO544

Bioelectrical Impedance Parameters as Earlier Predictors of Mortality/Survival in Ecuadorian Hemodialysis Patients

Session Information

• Hemodialysis: Biomarkers, Translational Research
  November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

• 801 Dialysis: Hemodialysis and Frequent Dialysis

Authors

• Santacruz, Juan Cristobal, Clínica de los Riñones Menydial, Quito, pichincha, Ecuador

Juan Cristobal Santacruz,

• Armijo, Kevin Gabriel, Clínica de los Riñones Menydial, Quito, pichincha, Ecuador

Kevin Gabriel Armijo,

• Baez, Layla N., Clínica de los Riñones Menydial, Quito, pichincha, Ecuador

Layla N. Baez,

• Arévalo, Paola Karina, Clínica de los Riñones Menydial, Quito, pichincha, Ecuador

Paola Karina Arévalo,

• Santacruz, Maria Gabriela, Clínica de los Riñones Menydial, Quito, pichincha, Ecuador

Maria Gabriela Santacruz,

• Sucre Guevara, Nairi Seleni Nasugue, Clínica de los Riñones Menydial, Quito, pichincha, Ecuador

Nairi Seleni Nasugue Sucre Guevara,

• Reinoso, Paulo, Clínica de los Riñones Menydial, Quito, pichincha, Ecuador

Paulo Reinoso,

• Santacruz, Angel Cristobal, Clínica de los Riñones Menydial, Quito, pichincha, Ecuador

Angel Cristobal Santacruz,

• Gavilanes, Veronica, Clínica de los Riñones Menydial, Quito, pichincha, Ecuador

Veronica Gavilanes,

Background

Bioelectrical impedance analysis (BIA) is a non-invasive test to assess body composition and water distribution. Nutritional and volume disturbances are related with mortality in hemodialysis (HD) population. Few is known about BIA parameters as mortality/survival predictors. The aim of the study was to study BIA parameters as mortality/survival predictors in HD patients.

Methods

Observational-prospective-cohort study from April 2021-2023 in one HD center. BIA analysis was performed in HD patients and parameters significatively related with mortality and survival were identified. ROC curves, regression and correlation analysis were performed in BCM parameters identified.

Results

A total of 115 patients were included, 9 (7,8%) died. Phase Angle (PA) (4.64°±1.11vs3.12°±0.62;p:0.01), Lean Tissue Index (LTI) (12.41Kg/m²±3.14vs9.75 Kg/m²±2.95;p0.02), Intracellular Water (ICW) (15.26L±3.53vs13.23L±4.97;p=0.03) were related with survival. Correlation analysis found positive correlation of PA (p<0.001), LTI (p=0.02) and ICW (p= 0,03) with survival. Age (53.98y±14.75vs70.67y±7.14; p<0.001) and E/I ratio (0.97±0.14vs1.17±0.16;p<0.001) were related with mortality. Age (p=0.002) and E/I ratio (p=0,005) had positive correlation with mortality.

Conclusion

Phase Angle, Intracellular water, E/I ratio, and Lean Tissue Index of a single non-invasive BIA can be used as earlier predictors of survival and mortality in HD patients allowing premature identification and intervention in this group of patients to reduce mortality risk.