Abstract: SA-PO539
Association Between Birth Weight Z-Score and Blood Pressure in Young Adults
Session Information
- Hypertension and CVD: Clinical - II
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1602 Hypertension and CVD: Clinical
Authors
- Sigurdardottir, Asdis H., Landspitali, Reykjavik, Iceland
- Indridason, Olafur S., Landspitali, Reykjavik, Capital, Iceland
- Stephensen, Sigurdur S., Landspitali, Reykjavik, Iceland
- Edvardsson, Vidar O., Landspitali, Reykjavik, Iceland
- Hrafnkelsdottir, Thordis J., Landspitali, Reykjavik, Iceland
Background
Low birth weight (BW) has been associated with increased risk of hypertension later in life. The aim of this study was to examine the association between BW weight z-score and blood pressure (BP) indices in healthy young adults.
Methods
Participants were recruited from a cohort of 970 adults aged 20-22-years who participated in a population-based study of BP in 9-10-year-old Icelandic children. All participants underwent 8 resting clinic BP measurements during two separate visits and an ambulatory BP (ABP) measurement. Birth weight and gestational age obtained from the Icelandic Birth Registry were used to calculate BW z-scores based on a standardized growth chart by Niklasson & Albertsson-Wikland. Pearson correlation coefficient and multivariable linear regression were used for analysis.
Results
Of 170 young adults who completed the follow-up study, 102 were women (60%). The mean clinic BP was 120/65 mm Hg in men and 112/66 mm Hg in women. The mean BW for men was 3625±736 g and 3646±592 g for women. A negative correlation was observed between BW z-score and both systolic and diastolic ABP (r= -0.14, p=0.026 and -0.10, p=0.20, respectively). When the sexes were analyzed separately the correlation between BW z-score and systolic ABP was statistically significant only in women (r=-0.24, p=0.014). In women the association between BW z-score and diurnal systolic ABP was significant (r=-0.26, p=0.013) while the correlation with nocturnal systolic ABP was not (r=-0.16, p=0.097). When adjusted for body mass index a significant association was detected between BW z-score and both systolic and diastolic ABP in young women (beta= -1.7, p=0.02 and beta= -1.2, p=0.01, respectively). This association was stronger for both diurnal systolic and diastolic ABP (beta= -1.8, p=0.02, and beta= -1.4, p=0.02), than for nocturnal ABP (beta= -1.4, p= 0.08, and beta= -0.79, p= 0.2). In men, BW z-score did not have a significant association with either ABP (systolic, r=-0.002 p=0.9; diastolic, r=-0.1 p=0.4) or clinic BP (systolic, r=-0.07 p=0.4; diastolic, r=-0.02 p=0.8) at follow-up.
Conclusion
Low BW z-score has a strong association with systolic ABP in young women and this relationship is stronger for diurnal systolic ABP.