Kidney Week

Abstract: TH-PO1017

Particulate Matter and Risk of CKD: A Global Exposure-Response Analysis

Session Information

• CKD Epidemiology, Risk Factors, Prevention - I
  November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Author

• Zhang, Feifei, Peking University Health Science Center, Beijing, Beijing, China

Feifei Zhang,

Background

Associations between particulate matter (PM) air pollution and chronic kidney disease (CKD) have been increasingly reported, yet the exposure-response association is insufficiently estimated. This study aimed to combine all available associations between PM of two different sizes (PM_2.5 and PM₁₀) and CKD to generate exposure-response functions over concentrations experienced by populations in the globe.

Methods

Based on data from two prospective, population-based cohorts in the United Kingdom and China (UK biobank and China Health and Retirement Longitudinal Study), we used the shape constrained health impact function to generate exposure-response functions between both PM_2.5 and PM₁₀ and CKD within each country. We then collected additional data on PM_2.5-CKD and PM₁₀-CKD associations from published literature and used the global exposure mortality model to construct exposure-response functions for CKD over a full range of global PM_2.5 and PM₁₀ concentrations.

Results

In the United Kingdom, the exposure-response functions for both PM_2.5 and PM₁₀ and CKD showed a linear association at lower concentrations and then a sublinear association at higher concentrations. In China, the risk of CKD also increased linearly with the increasing PM_2.5 and PM₁₀ at lower concentrations, but the associations for both air pollutants did not reach the statistical significance. After combining with all other published associations, the exposure-response function revealed a near linear association of the natural log relative risk of CKD with PM_2.5 (Figure 1a) and a sublinear association with PM₁₀ (Figure 1b), respectively.

Conclusion

Both PM_2.5 and PM₁₀ exposure increased the risk of CKD, particularly at higher concentrations. Our findings highlight the urgency for air pollution management in areas with severe PM pollution to protect kidney health.

Figure 1 Exposure-response relationships between particulate matter and chronic kidney disease. (a) PM_2.5, (b)PM₁₀. Red line represents the log (relative risk) and grey shaded area represents its 95% confidence intervals.