Abstract: SA-PO075
Persistent AKI Following Orthotopic Liver Transplant: Prevalence, Risk Factors, and Long-Term Renal Outcomes
Session Information
- AKI: Epidemiology, Risk Factors, Prevention - II
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Authors
- Del Toro-Cisneros, Noemi, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico
- Rivas Sánchez, Luis Ángel, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico
- Felix Bauer, Karina Charlotte, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico
- Pérez, Adela Uribe, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico
- Vega, Olynka, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico
Background
This study investigated the pre- and postoperative factors associated with the development of persistent AKI (AKI >72 hours of duration) post-transplant and its impact on renal function during a 5-year follow-up.
Methods
Retrospective study that included all patients who underwent OLT from January 2008 to December 2018. Demographic data, data inherent to the surgical procedure and post-operative factors associated with AKI. Subsequently, we performed logistic analysis with variables to predict persistent AKI. Finally, we analyzed the renal trajectory between the two groups: those with persistent AKI and those without it.
Results
305 patients were included, 23% developed persistent AKI post-OLH. Demographic characteristics, comorbidities, and perioperative variables are shown in Table 1. In the multivariate analysis, the significant variables are shown in Table 2. Mortality at hospital discharge was not different between the groups. In the analysis of the renal trajectories, the patients who presented persistent AKI had a lower eGFR with a median difference at 5 years of follow-up of 10ml/min/1.73m2.
Conclusion
In the present study, the factors associated with AKI development were: male gender, ascites drainage during surgery, diuresis <500ml in the first 24 hours post-OLT, use of antifungals, and anhepatic time >50 minutes. Long-term renal function in patients who developed persistent AKI deteriorated more compared to those who did not.