Abstract: SA-PO1099
Factors Influencing Quality of Life in Moderate to Severe CKD
Session Information
- CKD Epidemiology, Risk Factors, Prevention - III
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Polpattaraset, Cholwiwat, Mahidol University Faculty of Medicine Siriraj Hospital, Bangkok, Bangkok, Thailand
- Kiattisunthorn, Kraiwiporn, Mahidol University Faculty of Medicine Siriraj Hospital, Bangkok, Bangkok, Thailand
Background
Improving quality of life is one of the targets of CKD management which are involved in several factors including physical, mental and social factors. In addition to factors in general population, evaluation tools for health related QoL (HRQoL) in CKD patients should include kidney related parameters. KDQOL-SF1.3 is a tool developed and established to demonstrate QoL in ESRD, but data in non-dialysis CKD is scarce. Therefore, this study is to present factors contributing to HRQoL in stage 3-5 CKD.
Methods
There were 94 stage 3-5 CKD patients followed up at Siriraj CKD Clinic, Faculty of Medicine Siriraj Hospital, included into the study from November 2021 and August 2022. The data were collected at the baseline for age, gender, comorbidities, CKD etiology, household incomes and education, current medications and pill numbers, blood pressure, nutritional status, physical activity, muscle mass, handgrip strength, and physical performance. Laboratory data included serum creatinine based estimated CKD-EPI GFR, hemoglobin, serum albumin, calcium, phosphate and intact parathyroid hormone (PTH). HRQoL was assessed by KDQOL-SF1.3.
Results
Demographic data were demonstrated in table 1. There was no difference of overall scores of HRQoL in each stage of CKD (stage 3; 70.0 ± 15.3, stage 4; 69.0 ± 18.3 and stage 5; 73.5 ± 16.2; p = 0.545). However, lower HRQoL scores were associated with poor physical capacity parameters and PTH. Mean 6-minute walk test was 184.9 + 79.7 m vs. 259.1 + 89.4 m; p=0.002, median 5-times chair stand test was19.9 (7.9) vs. 13.2 (6.9) seconds; p=0.004 and metabolic equivalent of task (MET) was 100 (420) vs. 480 (2200) MET-min/week; p=0.009, among the patients with HRQoL <60 and >60, respectively. PTH was associated with lower physical component summary (PCS) scores [median PTH 149 (106) vs. 90.4 (94.0) pg/ml in PCS <38 vs. PCS >38, respectively; p=0.025].
Conclusion
Lower physical capacity is strongly associated with poor QoL in moderate to severe CKD. Factors associated with physical activity and skeletal health in CKD should be further evaluated to intervene for improving the outcomes.
Funding
- Government Support – Non-U.S.