Abstract: SA-PO1069
The Effect of Kidney Transplantation on Biventricular Structure and Function Evaluated by Transthoracic Echocardiography
Session Information
- Transplantation: Clinical - II
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 2102 Transplantation: Clinical
Authors
- Navarrete, Claudia Aline, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico
- Morales-Buenrostro, Luis E., Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico
- Joya Harrison, Jorge Armando, Tecnologico de Monterrey, Monterrey, Nuevo Leon, Mexico
- Marino-Vazquez, Lluvia A., Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico
- Martinez-Ibarra, Arturo Adrian, Tecnologico de Monterrey, Monterrey, Nuevo Leon, Mexico
- Baeza Herrera, Luis, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Ciudad de México, Mexico
Background
Kidney transplant (KT) recipients experience a higher risk of cardiovascular disease outcomes when compared with the general population. Due to the increasing number of patients requiring a transplant, better identification of cardiac risk is required to prevent premature death with a functioning graft.
Methods
We performed a single-center prospective and longitudinal study that included all transplant-eligible patients (living or deceased donors) from January-May 2022. The candidates underwent pre-transplant transthoracic echocardiography (TE) as per institutional protocol and a second one a year later. We excluded patients who were lost to follow-up or suffered a cardiovascular event during the studied period. The most representative cardiovascular structure and function values were evaluated.
Results
Seventeen patients were included a mean age of 50 years and 64.7% were men. The median time spent on dialysis was 2.6 years, 64.7% were on hemodialysis and 29.4% on peritoneal dialysis. Reverse remodeling of the left ventricular was observed following the KT as the LV mass decreased from 101 g to 82 g (p = 0.01).End-diastolic volume decreased from 124 to 100 ml (p=0.022), end-systolic volume from 52 to 30 mL (p= 0.031), and ejection fraction increased from 57% to 61% (p=0.06). E/e’ did not significantly change (9 vs 7.65 p= 0.14). Additionally, there were no statistically significant differences in left and right ventricle strain (18.5 vs 19.4 p=0.191 and 24 vs 24 p=0.55).
Conclusion
Reverse cardiac remodeling following the KT was observed as a reduction in left ventricle mass and improvement in ejection fraction, left and right ventricle strain did not change. Further description and understanding of cardiovascular function modification before and after KT is needed to improve graft and overall survival.