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Abstract: FR-PO836

Paradoxical Association of Vitamin D Supplementation with Elevated Blood Pressure in Individuals Without Vitamin D Deficiency

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1500 Health Maintenance, Nutrition, and Metabolism

Authors

  • Tanariyakul, Manasawee, University of Hawai'i at Manoa John A Burns School of Medicine, Honolulu, Hawaii, United States
  • Arayangkool, Chinnawat, University of Hawai'i at Manoa John A Burns School of Medicine, Honolulu, Hawaii, United States
  • Leesutipornchai, Thiratest, University of Hawai'i at Manoa John A Burns School of Medicine, Honolulu, Hawaii, United States
  • Aiumtrakul, Noppawit, University of Hawai'i at Manoa John A Burns School of Medicine, Honolulu, Hawaii, United States
  • Khan, Mohammad Iqbal, University of Hawai'i at Manoa John A Burns School of Medicine, Honolulu, Hawaii, United States
  • Tantisattamo, Ekamol, Division of Nephrology, Hypertension and Kidney Transplantation, Department of Medicine, University of California Irvine School of Medicine, Orange, California, United States
Background

While vitamin D(Vit D) deficiency(def) is associated with high blood pressure(BP), potential effects of supplemental Vit D intake on BP in individuals without Vit D def is unknown. This study aims to examine the association of the amount of Vit D intake with BP in individuals with and without Vit D def.

Methods

This cross-sectional study utilized data from the 2017-2018 Continuous NHANES. Participants' average daily Vit D intake over a 30-day period and their BP were collected through questionnaires and examinations. The study included individuals with more or less Vit D intake(>800 or <800IU/day). Difference in systolic and diastolic BP (SBP and DBP) between two groups stratified by presence and absence of Vit D def defined by Vit D level <30 and ≥30nmol/L, respectively was evaluated by an independent sample t-test.

Results

Among participants without Vit D def, 1068 had more and 837 had less Vit D intake. SBP in the former group were greater than those of the latter group (SBPmore vs less 128.95±20.46 vs. 120.37±19.22mmHg; meandifference 8.59mmHg, P <0.001). Similarly, DBP was higher in the more Vit D intake group (DBPmore vs less 70.02±15.09 vs. 67.66±16.35mmHg; meandifference 2.36mmHg, P <0.001). Of 90 participants with Vit D def (34 and 56 with more and less Vit D intake), both SBP and DBP remained higher in the more Vit D intake group but there was no statistical significance (SBPmore vs less 125.71±21.47 vs. 122.82±19.38mmHg; meandifference 2.88mmHg, P 0.513 and DBPmore vs less 70.71±10.17 vs. 69.68±10.79mmHg; meandifference 1.027mmHg, P 0.651)

Conclusion

Although Vit D supplementation is associated with lowering BP in individuals with Vit D def, supplemental Vit D intake greater than 800IU/day is paradoxically associated with higher BP in individuals without Vit D def compared to lesser Vit D takers. In the absence of Vit D def, whether Vit D supplementation causes an imbalance of mineral and bone metabolism related to vascular calcification leading to elevated BP requires further studies.