Kidney Week

Abstract: FR-OR66

Proenkephalin A 119-159 as a Novel Biomarker for Early Detection of Delayed Graft Function After Kidney Transplantation

Session Information

• Kidney Transplantation: Biomarkers, New and Old
  November 03, 2023 | Location: Room 115, Pennsylvania Convention Center
  Abstract Time: 05:15 PM - 05:24 PM

Category: Transplantation

• 2102 Transplantation: Clinical

Authors

• Nusshag, Christian, Heidelberg University Hospital Department of Nephrology, Heidelberg, Germany

Christian Nusshag, MD, DrMed

• Benning, Louise, Heidelberg University Hospital Department of Nephrology, Heidelberg, Germany

Louise Benning,

• Göth, Daniel, Heidelberg University Hospital Department of Nephrology, Heidelberg, Germany

Daniel Göth,

• Mahler, Christoph Friedrich, Heidelberg University Hospital Department of Nephrology, Heidelberg, Germany

Christoph Friedrich Mahler,

• Kälble, Florian, Heidelberg University Hospital Department of Nephrology, Heidelberg, Germany

Florian Kälble,

• Speer, Claudius, Heidelberg University Hospital Department of Nephrology, Heidelberg, Germany

Claudius Speer,

• Reineke, Marvin, Heidelberg University Hospital Department of Nephrology, Heidelberg, Germany

Marvin Reineke,

• Schmitt, Felix C.F., Heidelberg University Hospital Department of Anesthesiology, Heidelberg, Germany

Felix C.F. Schmitt,

• Mieth, Markus, Heidelberg University Hospital Department of General, Visceral and Transplantation Surgery, Heidelberg, Germany

Markus Mieth,

• Zeier, Martin G., Heidelberg University Hospital Department of Nephrology, Heidelberg, Germany

Martin G. Zeier,

• Mehrabi, Arianeb, Heidelberg University Hospital Department of General, Visceral and Transplantation Surgery, Heidelberg, Germany

Arianeb Mehrabi,

• Weigand, Markus A., Heidelberg University Hospital Department of Anesthesiology, Heidelberg, Germany

Markus A. Weigand,

• Morath, Christian, Heidelberg University Hospital Department of Nephrology, Heidelberg, Germany

Christian Morath,

Group or Team Name

• Group Nusshag.

Background

Delayed graft function (DGF) frequently occurs following kidney transplantation and adversely affects patient outcomes such as length of hospital stay, impaired long-term graft function and ultimately quality of life. Though a universal definition of DGF is lacking, a common classification is the need for dialysis in the first postoperative week excluding the first 24 hours. The aim of this study was to evaluate the capabilities of the novel kidney function biomarker proenkephalin A 119-159 (penKid) to predict DGF compared to serum creatinine (SCr).

Methods

In the currently ongoing study, penKid has been quantified from plasma using a chemiluminescence immunoassay in our daily routine in all freshly transplanted patients since November 2022. PenKid is quantified the day of transplantation and every weekday following transplantation. For this preliminary analysis, penKid levels were compared to SCr. The end of data collection is June 30, 2023.

Results

In a preliminary analysis including 70 kidney transplant recipients (70% cadavric transplants), results suggest, that penKid may discriminate patients with delayed graft function from patients with primary graft uptake earlier than SCr. In contrast to SCr, penKid was able to distinguish between DGF and no DGF as early as 24 hours after transplantation (Figure 1). In addition, other than SCr, penKid levels do not seem to be affected by dialysis.

Conclusion

PenKid is a promising new biomarker for the early prediction of DGF after kidney transplantation and may enable clinicians to adjust their treatment in high-risk patients accordingly. However, more clinical data is needed to validate our findings and to establish the clinical utility of penKid in the management of kidney transplant patients.