Abstract: SA-PO964
Patients with Primary Focal Segmental Glomerulosclerosis with Detectable Urinary CD80 Are More Similar to Patients with Minimal Change Disease in Clinicopathological Features
Session Information
- Glomerular Diseases: Translational Studies and Biomarkers
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Trials
Authors
- Gong, Xiaojie, Peking University First Hospital Department of Nephrology, Beijing, Beijing, China
- Huang, Jing, Peking University First Hospital Department of Nephrology, Beijing, Beijing, China
- Cui, Zhao, Peking University First Hospital Department of Nephrology, Beijing, Beijing, China
Background
Focal segmental glomerulosclerosis (FSGS) is an important cause of refractory nephrotic syndrome (NS) in children and adults. Urinary CD80 is elevated in some patients with primary FSGS, however, its clinical value is not fully clarified. This study aims to evaluate the clinical and pathological significance of urinary CD80 in patients with primary FSGS.
Methods
Sixty-one adult patients with biopsy-proven primary FSGS, with standard treatment and long-term follow up, were enrolled retrospectively. Urinary CD80, at the day of kidney biopsy, was measured using commercial ELISA kits and adjusted for urinary creatinine excretion. Their associations with clinical and pathological parameters were investigated.
Results
Urinary CD80 was detectable in 30/61 (49.2%) patients, who presented with a higher level of proteinuria (10.7 vs. 5.8 g/d; P=0.01), a lower level of serum albumin (19.3±3.9 vs. 24.2±8.2 g/L; P=0.005), a higher prevalence of hematuria (70.0 vs. 38.7 %; P=0.01), and showed lower percentage of segmental glomerulosclerosis lesion [4.8 (3.7-14.0) vs. 9.1 (5.6-21.1) %; P=0.06]. The cumulative relapse rate was remarkably high in these patients (log-rank, P=0.001). Multivariate analysis identified that the elevated urinary CD80 was an independent risk factor for steroid-dependent NS (OR 8.81, 95% CI 1.41-54.89; P=0.02) and relapse (HR, 2.87; 95% CI 1.29-6.38; P=0.01).
Conclusion
The elevated urinary CD80 is associated with mild pathological change and steroid-dependent cases of primary FSGS adults, which indicates these patients are more similar to minimal change disease (MCD).