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Abstract: SA-PO1100

An Investigation into the Relationship Between Frailty and Health-Related Quality of Life in Patients with CKD and Heart Failure

Session Information

Category: CKD (Non-Dialysis)

  • 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Tumelty, Ella H., St George's University Hospitals NHS Foundation Trust, London, United Kingdom
  • Mcnally, Thomas William, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
  • Chung, Isaac Wen Yao, St George's University of London, London, London, United Kingdom
  • Mookerjee, Souradip, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
  • Hussain, Sabba A., St George's University Hospitals NHS Foundation Trust, London, United Kingdom
  • Banerjee, Debasish, St George's University Hospitals NHS Foundation Trust, London, United Kingdom
  • Ali, Mahrukh Ayesha, St George's University of London, London, London, United Kingdom
Background

An increasing number of patients have comorbid Chronic Kidney Disease (CKD) and Heart Failure (HF); CKD-HF. Patients with CKD and HF have high frailty levels. Frailty is a predictor of morbidity; however, its association with health-related quality of life (HRQOL) is poorly understood. The aim of this study was to investigate the relationship between frailty and HR-QOL in patients with CKD-HF.

Methods

This was a single centre, cross-sectional study of adults with CKD stage 3-5 with HF. Frailty was defined as Modified Frailty Phenotype (MFP) score >=3. HRQOL was assessed using the validated Short Form (SF-36) Health Survey. All data was collected at one point in time.

Results

The characteristics of the 103 included participants were: median age 76 years (IQR 13), 62% (64/103) male, mean BMI was 28.7 (SD 6.3) and median eGFR 30 (IQR 17). Fifty-one (50%) of participants were frail, and 52 (51%) were non-frail according to the MFP. Compared to non-frail patients, frail patients had significantly worse physical functioning scores (frail 20.88+/-14.48, non-frail 53.24+/-25.94, p-value <0.001), general health scores (frail 29.51+/- 16.86, non-frail 45.00(+/-20.05, p-value <0.001), bodily pain scores (frail 46.29+/-33.60, non-frail 63.27+/-29.22, p-value 0.008), social functioning scores (frail 52.23+/-29.65, non-frail 72.58+/-28.05, p-value 0.001) and energy levels (frail 26.37+/-18.31, non-frail 49.71+/-19.22, p-value<0.001). Most respondents cited ‘better quality of life’ as their healthcare priority.

Conclusion

Better quality of life is a priority for patients with CKD-HF. Frailty is negatively associated with quality of life. Early detection and intervention of frailty should be a priority for healthcare professionals.

Graphs representing the relationship between frailty and several parameters of HR-QOL; energy, general health, physical functioning, social functioning, bodily pain and mental health.

Funding

  • Other NIH Support