Abstract: FR-PO832
Dietary Magnesium Intake and Kidney Stones: The National Health and Nutrition Examination Survey 2011-2018
Session Information
- Health Maintenance, Nutrition, Metabolism - II
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Shringi, Sandipan, Rhode Island Hospital, Providence, Rhode Island, United States
- Raker, Christina A., Lifespan Biostatistics, Epidemiology, Research Design, and Informatics Core, Providence, Rhode Island, United States
- Tang, Jie, Rhode Island Hospital, Providence, Rhode Island, United States
Background
The association between dietary magnesium intake (DMI) and kidney stone disease (KSD) is not clear.
Methods
We examined The National Health and Nutrition Examination Survey (NHANES) 2011-2018 and used logistic regression analyses adjusting for age, sex, race, BMI, histories of hypertension, diabetes, thiazide use, cigarette smoking, alcohol drinking, dietary intake of calories, protein, sodium, calcium, and, supplemental calcium and vitamin D to determine the independent associations between DMI and prevalent KSD.
Results
A total of 19271 participants were eligible for the final analysis which included 1878 people who self-reported a history of the stone. The mean DMI was 295.4mg in stone formers and 309.6 mg in non-stone formers, p=0.02 (Table 1). Stone formers tended to be older, more likely to be male and Caucasian, and had a higher BMI. In univariate analysis, lower DMI was strongly associated with increased odds of prevalent KSD when DMI was modeled as a continuous variable (OR 0.94, 95% CI: 0.89-0.99, p=0.02) or when comparing the highest quartile of DMI to the lowest quartile (OR=0.74, 95% CI: 0.60-0.92, p=0.007). As shown in Table 2, after regression analysis, when DMI was modeled as a continuous variable odds of prevalent KSD were 0.92, with 95% CI: 0.84-1.01, p=0.07 but was strongly associated when comparing the highest quartile of DMI to the lowest quartile (OR=0.70, 95% CI: 0.52-0.93, p=0.01).
Conclusion
Our study suggests that higher DMI is associated with a reduced risk of kidney stone disease. Future prospective studies are needed to clarify the causal relationship.