Abstract: SA-PO1125
Risk of Incident CKD Among Patients with Urolithiasis: A Nationwide Longitudinal Cohort Study
Session Information
- CKD Epidemiology, Risk Factors, Prevention - III
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Park, Kyoung Sook, National Health Insurance Service Ilsan Hospital, Goyang, Gyeonggi-do, Korea (the Republic of)
- Kim, Jae Young, National Health Insurance Service Ilsan Hospital, Goyang, Gyeonggi-do, Korea (the Republic of)
Background
Urolithiasis has been infrequently implicated to have a causal association with chronic kidney disease (CKD). Recently, several studies have demonstrated the relationship between urolithiasis and CKD. However, the generalizability of their results is limited. We aimed to examine the association between the long-term effects of urolithiasis and the risk of incident CKD.
Methods
From the longitudinal National Health Insurance Service data, this nationwide population-based cohort study identified 219,570 Korean adults with incident urolithiasis requiring procedural interventions and without prior kidney disease and 219,570 controls without urolithiasis matched by age and sex. The primary outcome of interest was the de novo development of CKD, defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2 for at least two consecutive measurements at least 90 days apart. In the sensitivity analyses, the risk of incident CKD was further examined using the outcome defined by the newly occurring diagnostic codes indicating CKD.
Results
Over a mean follow-up of 6.0 years, 12,338 (2.8%) primary outcome events of CKD were observed, with an incidence rate of 4.6 per 1,000 person-years. Multivariable Cox analysis revealed that patients with urolithiasis were associated with a higher risk of incident CKD compared with controls, with an adjusted hazard ratio of 1.41 (95% confidence interval, 1.36–1.46). This association remained consistent across all clinically relevant subgroups and when the CKD outcome was defined based on the diagnostic codes in the sensitivity analysis.
Conclusion
In this large national cohort study, patients with urolithiasis were associated with a higher risk of incident CKD than those without urolithiasis. Further studies are warranted to establish the benefits of preventing urolithiasis in reducing CKD development.