Abstract: FR-PO870
Maternal Exposure to Tetrahydrocannabinol (THC) During Pregnancy Increases Kidney Damage in Mouse Offspring
Session Information
- Women's Health and Kidney Diseases
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Women's Health and Kidney Diseases
- 2200 Women's Health and Kidney Diseases
Authors
- Emami Naeini, Sahar, Augusta University, Augusta, Georgia, United States
- Salles, Evila, Augusta University, Augusta, Georgia, United States
- Bhandari, Bidhan, Augusta University, Augusta, Georgia, United States
- Saad, Karim Mohamed Mostafa, Augusta University, Augusta, Georgia, United States
- Rezaee, Sholeh, Augusta University, Augusta, Georgia, United States
- Elmarakby, Ahmed A., Augusta University, Augusta, Georgia, United States
- Yu, Jack C., Augusta University, Augusta, Georgia, United States
- Wang, Lei, Augusta University, Augusta, Georgia, United States
- Baban, Babak, Augusta University, Augusta, Georgia, United States
Background
Maternal use of cannabis during pregnancy has been associated with adverse effects on fetal development. However, little is known about the impact of maternal cannabis use on kidney development in offspring. In this study, we investigated the effects of maternal exposure to placebo, CBD, and THC inhalers on kidney damage in mouse offspring.
Methods
Pregnant mice were randomly assigned to receive either a placebo, CBD, or THC inhaler throughout pregnancy. Offspring kidneys were collected at birth and evaluated for kidney damage using the Kim-1 antibody. The percentage of Kim-1 was measured using flow cytometry.
Results
Kim-1 expression higher in THC treated group compared to the placebo and CBD groups, suggesting more kidney injuries in THC treated animals.
Conclusion
Our findings suggest that maternal exposure to THC during pregnancy may increase the risk of kidney damage in offspring. These results highlight the need for further research on the potential long-term effects of cannabis use during pregnancy.