Kidney Week

Abstract: SA-PO839

Prediction of Post-Donation Kidney Function for Persons Considering Living Kidney Donation

Session Information

• Transplantation: Clinical - Pretransplant Assessment and Living Donors
  November 05, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
  Abstract Time: 10:00 AM - 12:00 PM

Category: Transplantation

• 2002 Transplantation: Clinical

Authors

• Al Ammary, Fawaz, Johns Hopkins University, Baltimore, Maryland, United States

Fawaz Al Ammary,

• Muzaale, Abimereki, Johns Hopkins University, Baltimore, Maryland, United States

Abimereki Muzaale,

• Massie, Allan, Johns Hopkins University, Baltimore, Maryland, United States

Allan Massie,

Background

Healthy adults who donate a kidney lose 50% of their nephron mass following nephrectomy. However, kidney reserve may vary by donor health and demographic characteristics. We aimed to predict 6-month post-donation eGFR (6M-eGFR).

Methods

We used the US national registry of 60,584 living kidney donors from 2005-2019 to identify the clinical phenotypes associated with 6M-eGFR. We estimated eGFR for each participant using the CKD-EPI 2009 creatinine equation for eGFR. We built multivariable regression models of 6M-eGFR on baseline donor factors.

Results

The median (IQR) pre-donation and post-donation eGFR was 98 (86-110) and 64 (54-75). For 30-year-old female who were biologically related with the recipient and had no hypertension, no history of smoking, BMI=25, and predonation eGFR 100 ml/min/1.73m2, the predicted 6M-eGFR was 69 ml/min/1.73m² for white, 66 ml/min/1.73m² for black, 71 ml/min/1.73m² for Asian, and 73 ml/min/1.73m² for Hispanic donors.

Conclusion

Post-donation six-month compensatory kidney function varies by donor demographic and health characteristics. Our prediction of individualized 6M-eGFR helps inform donor selection and counseling of persons who consider donation.

Funding

• NIDDK Support