Abstract: PUB271
Indications and Complications Associated With Centrifuge-Based Therapeutic Plasma Exchange
Session Information
Category: Pathology and Lab Medicine
- 1700 Pathology and Lab Medicine
Authors
- Warner, David M., University of Cincinnati, Cincinnati, Ohio, United States
- Gudsoorkar, Prakash Shashikant, University of Cincinnati, Cincinnati, Ohio, United States
- Anand, Manish, University of Cincinnati, Cincinnati, Ohio, United States
Background
Therapeutic Plasma Exchange (TPE) is an extracorporeal treatment modality for management of certain diseases. To investigate the indications and safety of TPE, a retrospective review was conducted to identify the indications for TPE and the associated complications.
Methods
This is a single center retrospective review of centrifuge based TPE performed by the nephrology department at a tertiary care academic center between June 2018 to July 2019. Overall, 320 TPE treatments were performed on 44 patients.
Results
In total, there were fourteen diagnostic indications for TPE (Fig 1) along with their category of indication based on the American Society for Apheresis (ASFA) guidelines. The most common indication was myasthenia gravis, followed by autoimmune encephalitis and Antibody-Mediated Rejection (AMR) in kidney transplant recipients. Complications are documented in Fig 2. The most common complications were coagulopathy (43%), hypokalemia (41%), hyperglycemia (41% each), and hypotension (27%).
Conclusion
Overall, 14 diseases were noted as indications for TPE with myasthenia gravis being the most common. In terms of complications, depletion coagulopathy, hyperglycemia, and hypokalemia were the most common. This study exemplifies the utility of having a systematic audit to review the practice patterns and complications of TPE.
Indications for TPE
Complications of TPE