Abstract: FR-PO886
Gender Disparity in CKD: Men From Mars, Women From Venus
Session Information
- Diversity and Equity in Kidney Health - II
November 04, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Diversity and Equity in Kidney Health
- 800 Diversity and Equity in Kidney Health
Authors
- Sahay, Manisha, Osmania Medical College, Hyderabad, Telangana, India
- Kumar, Vivek, Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India
- Kundu, Monica, The George Institute for Global Health, Newtown, New South Wales, Australia
- Yadav, Ashok Kumar, Post Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India
- Jha, Vivekanand, The George Institute for Global Health, Newtown, New South Wales, Australia
Group or Team Name
- ICKD study group
Background
There is no data on sex difference in CKD in developing countries. We examined sex differences in pan-country prospective, observational cohort study
Methods
We used data from 1331 women & 2725 men with eGFR 15–60 mL/min/1.73 m2 or >60 mL/min/1.73 m2 with proteinuria from different geographical regions & compared demographics, clinical profile, QOL & Outcomes-ESKD(CKD 5/chronic dialysis/kidney transplantation), 50% decline in eGFR & mortality
Results
Cause of CKD was DKD (24.9% in men, 25% in women), CIN (22.8% in men , 24% in women) and unknown 20% in men and 18.3% in women. Urine albumin, BMI, waist-hip ratio, LDL, Phosphours, PTH were higher in females while serum haemoglobin and calcium, use of iron,erythropoietin & statin were lower. SGA scores were similar. Men had better QOL.There was no significant difference in renal outcomes or mortality (Fig1,2)
Risk factors for mortality, 50% GFR decline, incident ESRD are shown in Table1
Conclusion
This largest CKD cohort study with detailed phenotyping, rigorous follow-up showed that Women have poor literacy, QOL.hemoglobin, lower iron, ESA, statin use. Risk of progression to ESKD & mortality slightly more in women.
Table 1 Risk factors for renal outcomes and all cause mortality
| Males | Females | |
| risk factor for all cause mortality | Age (HR = 1.03, p = 0.01), sedentary lifestyle (HR = 0.62, p = 0.04), history of renal stone (HR=0.45, p = 0.05), history of CVD (HR=2.04, p <0.01) and BMI (HR = 0.92, p = 0.01 | Age (HR = 1.04, p = 0.02) |
| Risk of =/>50% GFR decline | Systolic BP (HR= 1.01, p = 0.01) NSAID (HR= 2.14, p <0.01) | Age (HR= 0.97, p = 0.010, ABI, systolic bp (HR = 1.04, p < 0.01), diastolic bp (HR = 0.96, p ,0.01) and NSAID (HR = 2.14, p = 0.05). |
| Risk factors for incident ESRD | age (HR = 0.98, p = 0.01), history of renal stones (HR = 0.54, p = 0.05), systolic BP (HR = 1.02, p <0.01) | ABI, systolic bp (HR = 1.02, p =0.02) and history of renal stone (HR= 0.34, p = 0.05 |
Funding
- Government Support – Non-U.S.