Kidney Week

Abstract: SA-PO439

Comparison Between Incremental and Conventional Hemodialysis in a Single Center

Session Information

• Hemodialysis and Frequent Dialysis: Clearance, Technology, Infection
  November 05, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
  Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

• 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

• Jung, Sehyun, Gyeongsang National University Hospital, Jinju, Korea (the Republic of)

Sehyun Jung,

• Lee, Seunghye, Gyeongsang National University Hospital, Jinju, Korea (the Republic of)

Seunghye Lee,

• Jang, Ha nee, Gyeongsang National University Hospital, Jinju, Korea (the Republic of)

Ha nee Jang,

• Chang, Se-Ho, Gyeongsang National University Hospital, Jinju, Korea (the Republic of)

Se-Ho Chang,

• Kim, Hyun-Jung, Gyeongsang National University Hospital, Jinju, Korea (the Republic of)

Hyun-Jung Kim,

Background

Residual kidney function (RKF) in dialysis patients contributes to removing body fluids and salts, improving blood pressure, and enhancing middle molecules clearance. According to retrospective data, incremental hemodialysis (HD) may preserve RKF. However, its efficacy and safety are controversial compared to conventional HD.

Methods

This was a single-center retrospective study for comparison between incremental and conventional HD for one year. Inclusion criteria of incremental HD were urine output above 600ml/day and residual renal urea clearance (Kru) above 3ml/min/1.73m². Among already maintenance HD patients, 21 patients changed to incremental HD (one or two times a week) and 54 patients maintained conventional HD (three times a week).

Results

There were three deaths in incremental HD group. Blood pressure and blood chemistry data at selected time points are shown in Table 1.
Study arm between both groups in mixed effect models did not show significant parameters that were blood pressure, serum sodium, potassium, calcium, phosphate, protein, albumin, total cholesterol, glucose, and C-reactive protein. However, serum total CO₂ decreased significantly, and serum chloride was significantly higher in the incremental HD than in the conventional HD (Figure.1).

Conclusion

Incremental HD was not inferior to conventional HD. But, serum bicarbonate and chloride can be under-dialysis in the incremental HD, so careful observation is required in this group.

Table 1. Blood pressure and blood chemistry data

Figure 1. Serum total CO₂ (A), serum Chloride (B) during study.