Abstract: FR-PO413
Relationships Between BSA-Adjusted Total Kidney Volume and Estimated Glomerular Filtration Rate in Pediatric CKD: Data From the KNOW-Ped CKD Study
Session Information
- Pediatric Nephrology - I
November 04, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Pediatric Nephrology
- 1800 Pediatric Nephrology
Authors
- Kim, Ji hyun, Seoul National University Bundang Hospital, Seongnam, Korea (the Republic of)
- Ahn, Yo Han, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
- Yang, Eun mi, Chonnam National University Medical School, Gwangju, Korea (the Republic of)
- Kang, Hee Gyung, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of)
- Cho, Min Hyun, Kyungpook National University Hospital, Daegu, Korea (the Republic of)
- Han, Kyoung Hee, Jeju National University Hospital, Jeju, Korea (the Republic of)
Background
The purpose of this study was to investigate the relationship between the estimated glomerular filtration rate (eGFR) and the renal volume adjusted for the body surface area through renal ultrasound in pediatric chronic kidney disease (CKD) in Korea.
Methods
Among the subjects enrolled in the KNOW-ped CKD cohort, 336 patients who underwent renal ultrasonography were investigated for renal lengths and widths on the longitudinal plane and the depth on the transverse plane. The formula to calculate the kidney volume was used with 0.523*length*width*depth and was corrected for the body surface area(BSA). The relationship between renal volume and the eGFR at the time of ultrasound measurement was analyzed. In addition, a survival analysis between the renal volume and medical events including renal replacement therapy was performed.
Results
The eGFR and BSA-adjusted kidney volume showed a significant correlation (R=0.209, P=0.000) in pediatric CKD with congenital anomalies of the kidney and urinary tract (CAKUT). Kaplan-Meier analysis showed a significantly higher proportion of a 2-fold increase of serum creatinine or medical events of end-stage renal disease (ESRD) according to BSA-adjusted kidney volume (log-rank test, χ2=17.901, P<0.001).
Conclusion
The BSA-adjusted kidney volume through renal ultrasound is a marker for kidney survival in pediatric CKD, especially with CAKUT.
Funding
- Government Support – Non-U.S.