Kidney Week

Abstract: TH-PO880

Cognitive Patterns in Patients With CKD: The CKD-REIN Cohort Study

Session Information

• CKD: Epidemiology, Risk Factors, Prevention - I
  November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2201 CKD (Non-Dialysis): Epidemiology‚ Risk Factors‚ and Prevention

Authors

• Levassort, Hélène, Clinique Ambroise Pare Service de Court Sejour Geriatrique, Boulogne-Billancourt, Île-de-France, France

Hélène Levassort,

• Massy, Ziad, Hopital Ambroise-Pare Service de Nephrologie Dialyse, Boulogne-Billancourt, Île-de-France, France

Ziad Massy,

• Lambert, Oriane, Centre de Recherche en Epidemiologie et Sante des Populations, Villejuif, Île-de-France, France

Oriane Lambert,

• Combe, Christian, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, Aquitaine, France

Christian Combe,

• Fouque, Denis, Universite Claude Bernard Lyon 1, Villeurbanne, Auvergne-Rhône-Alpes , France

Denis Fouque,

• Laville, Maurice, Universite de Lyon, Lyon, Auvergne-Rhône-Alpes , France

Maurice Laville,

• Ayav, Carole, Centre hospitalier regional universitaire de Nancy, Nancy, Lorraine, France

Carole Ayav,

• Jacquelinet, Christian, Agence de la biomedecine, La Plaine Saint-Denis, France

Christian Jacquelinet,

• Stengel, Benedicte, Centre de Recherche en Epidemiologie et Sante des Populations, Villejuif, Île-de-France, France

Benedicte Stengel,

• Pépin, Marion, Clinique Ambroise Pare Service de Court Sejour Geriatrique, Boulogne-Billancourt, Île-de-France, France

Marion Pépin,

Group or Team Name

• Center for research in Epidemiology and Population Health (CESP), Clinical Epidemiology Team, Paris-Saclay University, Versailles Saint-Quentin-en-Yvelines University, National Institute of Health and Medical Research, Villejuif, France

Background

Chronic kidney disease (CKD) is associated with an increased risk of neurocognitive disorders (NCD). The global Mini Mental State Examination (MMSE) is often used to screen for cognitive impairment in patients with CKD, but the relative impact of CKD on the different cognitive domains of MMSE remains unexplored

Methods

We used the MMSE to assess orientation, memory, attention and calculation, langage and praxis, scores among 3033 patients (mean age, 66.82±12.87; 65.3% men) with all types of CKD and an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m² included in the CKD-Renal Epidemiology and Information Network (CKD-REIN) cohort. Adjusted associations of patient characteristics with the global and domain-specific MMSE scores were estimated using linear regression models.

Results

The mean global MMSE score was 26.8/30 and the median score was 28/30. Two cognitive domains were significantly lower at lower eGFR level: orientation and praxis. After adjusting for age, sex, education, depressive symptoms, polymedication, psychoactive drug use, cerebrovascular disease, heart failure, history of depression and urinary albumin/creatinine ratio, low eGFR (expressed as 10 mL/min/1.73 m²), the orientation score was significantly lower, by 0.03 points [0.003, 0.05] for every 10 mL/min/1.73 m² drop in eGFR (p=0.03), and praxis, by 0.01 points [0.002, 0.02] (p=0.01).

Conclusion

This study shows that orientation and praxis domains may be affected before the occurrence of clinically evident NCD, in patients with nondialysis CKD. This highlights the importance of screening individual cognitive domains in this population.

Funding

• Other NIH Support