Kidney Week

Abstract: TH-PO881

Comparison Between the Profile of Patients Defined by Age-Adapted and Fixed-Threshold CKD Criteria: A National-Wide, Cross-Sectional Study

Session Information

• CKD: Epidemiology, Risk Factors, Prevention - I
  November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2201 CKD (Non-Dialysis): Epidemiology‚ Risk Factors‚ and Prevention

Authors

• Ma, Yixin, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China

Yixin Ma,

• Lin, Jianfeng, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China

Jianfeng Lin,

• Xia, Peng, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China

Peng Xia,

• Zheng, Hua, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China

Hua Zheng,

• Ji, Peili, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China

Peili Ji,

• Zhu, Guangjin, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China

Guangjin Zhu,

• Qiu, Ling, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China

Ling Qiu,

• Chen, Limeng, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China

Limeng Chen,

Background

Kidney function declines with advancing age, an age-adapted eGFR threshold has been proposed instead of the fixed cutoff for CKD definition. The study aims to describe and compare the profile of CKD patients defined by these two criteria in a Chinese population.

Methods

We recruited the adult participants with selected biochemical tests from the Chinese Physiological Constant and Health Condition (CPCHC) survey conducted from 2007 to 2011, with the GFR estimated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. The age-adapted threshold of eGFR was 75, 60, and 45 mL/min/1.73 m² for the population under 40 years old, 40 to 64 years old, and above 64 years, respectively. The fixed threshold is 60 mL/min/1.73 m2 for all ages.

Results

Among the recruited 23,438 participants, 480 participants were diagnosed with CKD by fixed-threshold criteria, 391 participants by age-adapted criteria. We found that the CKD patients defined by age-adapted criteria matched well with the 2.5th percentile of eGFR in the Chinese individuals. When compared with their age-and gender-matched controls, patients included by age-adapted criteria but excluded by fixed-threshold criteria had a significantly higher prevalence of hypertension (23.2% vs. 7.7%, p<0.001) and hyperuricemia (25.0% vs. 5.5%, p<0.001), while patients included only by the fixed-threshold criteria were not significantly different in CVD risk factors and CKD related disturbance except for hyperuricemia (41.2% vs. 14.0%, p<0.001).

Conclusion

An age-adapted criterion is more closely associated with CVD risk factors and CKD-related disturbance compared to fixed-threshold criteria.

Figure 1. Illustration of age and eGFR distribution and the CVD risk profile of patients

Funding

• Government Support – Non-U.S.