Abstract: SA-PO334
Association of uTWEAK Levels with Histological Findings, Endothelial and Tubulointerstitial Markers (VEGF/VCAM-1, TGFβ) in Patients with Lupus Nephritis (LN)
Session Information
- Cellular Crosstalk in Glomerular Diseases - II
October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1201 Glomerular Diseases: Fibrosis and Extracellular Matrix
Authors
- Reyes, Fabiola, IMSS, México, Ciudad de México, Mexico
- Toledo, Germain, IMSS, México, Ciudad de México, Mexico
- Soto, Virgilia, INC Ignacio Chavez, Mexico City, Mexico
- Perez-Navarro, L. Monserrat, Hospital General de México Dr. Eduardo Liceaga, México, Mexico
- Valdez-Ortiz, Rafael, Hospital General de Mexico, Mexico City, DISTRITO FEDERAL, Mexico
Background
Urinary TWEAK levels (uTWEAK) are a sensitive and specific biomarker in the evaluation of LN in patients with SLE, however, its association with histological findings and expression of endothelial and tubulointerstitial lesion marker is unknown.
Methods
Cross-sectional study. We determinate the degree of association between uTWEAK with histological findings and markers of endothelial lesion (VEFG and VCAM-1) and tubulointerstitial (TFGβ) in patients with LN that have not been received immunosuppressive treatment. Non parametric statistics, logistic regression model, 95%CI, and p <0.05 were performed as statistically significant.
Results
Thirty-six patients were evaluated, 83.3% (30) were female. With predominance of histological class IV+V (41.6%). In the histological findings, 63.8% had a low chronicity index (<6 points), the activity index (AI) was 50% >12 points. The uTWEAK according to the histological class did not show statistically significant differences. In 72.2% of the patients, VEGF at glomerular was ≥50% and at the arteriolar level, 77.8% of the patients presented deposits of ≥50%. In Figure 1, the correlation between the histological findings and the endothelial and tubolointerstitial biomarkers is observed. Although, uTWEAK was not associated significantly with AI and arteriolar VEGF deposits (OR 4.18, p= 0.223 and 11.298, p= 0.120), effect size (d-Cohen) was of 0.78 and 1.33 respectively.
Conclusion
The uTWEAK represents a sensitive and specific biomarker in the evaluation of LN in patients with SLE, however, his expression does not seem to distinguish between the different classes of LN; an association was found with AI and VEGF. It is relevant to evaluate the outcome of the patients and to establish if the markers evaluated have an impact on the prognosis of the patients.