Abstract: SA-PO899
Blood Myostatin Levels Are Related with Abdominal Aortic Calcification in Dialysis Patients
Session Information
- Dialysis: Cardiovascular, BP, Volume
October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Lee, Su mi, Dong-A University, Busan, Korea (the Republic of)
- Oh, Yun Jung, Cheju Halla General Hospital, Jeju, Korea (the Republic of)
- Son, Young ki, Dong-A University, Busan, Korea (the Republic of)
- Kim, Seong Eun, Dong-A University Hospital, Busan, Korea (the Republic of)
- An, Won Suk, Dong-A University, Busan, Korea (the Republic of)
Background
Myostatin which is a member of the transforming growth factor-β superfamily, regulates synthesis and degradation of skeletal muscle protein and it is up-regulated in the skeletal muscle of chronic kidney disease (CKD) patients. There are few studies on relationship between myostatin levels and vascular calcification, important risk factors for cardiovascular disease in CKD. The aim of this study was to assess the association between serum myostatin levels and abdominal aortic calcification (AAC) in patients with dialysis.
Methods
In this cross-sectional study, 71 outpatients undergoing dialysis were included. We assessed AAC semiquantitatively from the lateral lumbar spine obtained using plain radiograph. Serum myostatin level was determined by commercially available enzyme-linked immunosorbent assay and divided by median for analysis.
Results
Our study included 37 hemodialysis patients and 34 peritoneal dialysis (PD) patients with a median age of 59.0 years and a median myostatin level of 4991.4 pg/mL. Patients with low myostatin level were older and had a higher proportion of men, PD, and AAC scores ≥ 5 than those with high myostatin level. The median myostatin level for patients with AAC scores ≥ 5 was 4073.5 pg/mL, whereas that for AAC scores <5 was 5838.6 pg/mL. Age and AAC scores showed a significantly negative correlation with myostatin levels. After adjustment for potential confounding factors, including age, gender, diabetes mellitus, dialysis vintage, dialysis modality, osteoprotegerin, and AAC score ≥ 5, the presence of AAC was significantly and negatively associated with serum myostatin levels.
Conclusion
Low serum myostatin levels were associated with elevated AAC scores in dialysis patients. Further studies are necessary to determine the significance of measuring serum myostatin level in patient with dialysis.