Kidney Week

Abstract: SA-PO653

Bone Mineral Density and Handgrip Strength in Early CKD: Cross-Sectional Analysis of CARTaGENE

Session Information

• Bone and Mineral Metabolism: Clinical - II
  October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Bone and Mineral Metabolism

• 402 Bone and Mineral Metabolism: Clinical

Authors

• Desbiens, Louis-Charles, CHU de Québec - Université Laval, Québec, Quebec, Canada

Louis-Charles Desbiens,

• Goupil, Remi, Hopital du Sacre-Coeur de Montreal, Montreal, Quebec, Canada

Remi Goupil,

• Madore, Francois, Hopital du Sacre-Coeur de Montreal, Montreal, Quebec, Canada

Francois Madore,

• Mac-Way, Fabrice, CHU de Québec - Université Laval, Québec, Quebec, Canada

Fabrice Mac-Way,

Background

Bone mineral density (BMD) and handgrip strength (HGS) are associated with adverse outcomes in general and advanced CKD populations. However, how early CKD impacts these two parameters has not been well studied.

Methods

Cross-sectional analysis of CARTaGENE, a population-based health survey of 40 to 69 years old individuals from Quebec. Individuals with data on estimated glomerular filtration rate (eGFR) over 30 ml/min/1,73m², BMD and HGS were included. BMD was measured by quantitative ultrasound at the calcaneus and HGS by a hand dynamometer. Early CKD was expressed continuously (eGFR) and categorically (KDIGO stages). Association between CKD, BMD and HGS was assessed with linear regression in univariate and multivariate models adjusted for demographics, comorbidities and medication. BMD results were stratified for sex because of an interaction between CKD and sex.

Results

We included 15,721 individuals (51% male with a mean age of 54 years and a mean eGFR of 88 ml/min/1.73m²). 47% of individuals had G2 CKD and 4% G3 CKD. Mean BMD t-score was 0.19 in non-CKD individuals, 0.22 in G2 CKD and 0.08 in G3 CKD (G3 vs G1-G2 p=0.01). Mean HGS was 68kg in non-CKD individuals, 69kg in G2 CKD and 64kg in G3 CKD (G3 vs G1-G2 p<0.001). In univariate analysis, eGFR was not associated with HGS, but was positively associated with BMD in men and negatively in women. In adjusted models, eGFR was negatively associated with both HGS and BMD (Table). G2 and G3 CKD were associated with higher HGS compared to non-CKD. G2 CKD was associated with increased BMD in both men and women while G3 CKD was associated with increased BMD in men only.

Conclusion

In a large population of 40 to 69 years old individuals and in contrast to advanced CKD, early CKD is not associated with a decrease in BMD and HGS.

Funding

• Government Support - Non-U.S.