Kidney Week

Abstract: SA-PO684

Correlation of Vitamin D and Insulin Resistance Among Calcium Kidney Stone Formers

Session Information

• Bone and Mineral Metabolism: Clinical - II
  October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Bone and Mineral Metabolism

• 402 Bone and Mineral Metabolism: Clinical

Authors

• Gandhi, Pulkit, Brown University, Providence, Providence, Rhode Island, United States

Pulkit Gandhi,

• Gandhi, Roopali Goyal, Rhode island hospital, PROVIDENCE, Rhode Island, United States

Roopali Goyal Gandhi,

• Tang, Jie, University Medicine; Brown University, West Roxbury, Massachusetts, United States

Jie Tang,

Background

Existing evidence suggest that vitamin D could play a role in the pathogenesis of type 2 diabetes, by affecting insulin sensitivity. However, the interaction of 25(OH)-vitamin D (25D) with insulin sensitivity has not been examined in calcium kidney stone formers, a unique population whose 1,25(OH) vitamin D (1,25-D) action seems to be hyperactive.

Methods

Prevalent non-diabetic calcium kidney stone formers from 2015 to 2018 were enrolled in this study. We assessed the association between serum 25D and insulin resistance measured by Homeostatic model assessment insulin resistance {HOMA IR = (fasting glucose (mg/dl) × fasting insulin (mU/L)/(405)} using univariate analysis and multivariate regression model adjusting for demographics and important clinical covariates. P values less than 0.05 were considered significant.

Results

A total of 94 non-diabetic calcium kidney stone formers were enrolled in this study. Among them, 51% were male, 86% were Caucasian, 38% had history of hypertension, and 29% had history of dyslipidemia. Mean age was 54 years, mean creatinine clearance (CrCl) was 131 ml/min, mean body mass index was 31.3 kg/m², mean serum 25D was 28 ng/ml, mean serum 1,25D was 52 pg/ml and mean serum parathyroid hormone level was 66 pg/ml. The mean HOMA IR was calculated at 8.1. In univariate analysis, 25D had no significant association with HOMA-IR (p=0.68), however, hypertension, dyslipidemia, CrCl and BMI associated significantly with HOMA-IR (p<0.05). After adjusting for demographics, 25D again did not associate significantly with HOMA-IR (p=0.33), but the associations between HOMA-IR and hypertension, dyslipidemia, CrCl and BMI remained significant (p<0.05). Finally, after adjusting for demographics, hypertension, dyslipidemia, CrCl, BMI and serum uric acid, the association between 25D and HOMA-IR remained insignificant (p=0.14). Like 25D, serum 1,25D levels had no association with HOMA-IR in univariate and multivariate analyses.

Conclusion

Unlike the general population, low serum 25D levels, had no significant association with insulin-resistance measured by HOMA IR in calcium kidney stone formers.

Funding

• Private Foundation Support