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To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Journal Club

Tuesday, December 16, 2025 | 12:00 PM – 1:00 PM ET

Hosted by the American Society of Nephrology

Featured article: Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease

NEJM: Published February 7, 2025 | N Engl J Med 2025;392:1933-1940 | DOI: 10.1056/NEJMoa241274

Volume 392 Number 19 | Copyright © 2025

In this article:

    Xenotransplantation offers a potential solution to the organ shortage crisis. A 62-year-old hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access challenges received a gene-edited porcine kidney with 69 genomic edits, including deletion of three glycan antigens, inactivation of porcine endogenous retroviruses, and insertion of seven human transgenes. The xenograft functioned immediately. The patient's creatinine levels decreased promptly and progressively, and dialysis was no longer needed. After a T-cell–mediated rejection episode on day 8, intensified immunosuppression reversed rejection. Despite sustained kidney function, the patient died from unexpected, sudden cardiac causes on day 52; autopsy revealed severe coronary artery disease and ventricular scarring without evident xenograft rejection. (Funded by Massachusetts General Hospital and eGenesis.)


    Registration is complimentary. 
      REGISTER


      Speaker

                       Leonardo Riella    
                     Leonardo V. Riella, MD, PhD, FASN, FAST
      Harold and Ellen Danser Endowed Chair in Transplantation
      Medical Director of Kidney Transplantation
      Associate Director, Legorreta Center for Clinical Transplant Tolerance 
      Massachusetts General Hospital
      Associate Professor of Medicine and Surgery
           Harvard Medical School
         
                                             
                              
         

        Moderators                   
                                         
                                         Amanddep Bajwa   
                             Amandeep Bajwa, PhD
                                  Associate Professor    
                                 The University of Tennessee 
                                       Health Science Center       
                                      Leslie Gewin    
                               Leslie Gewin, MD
                                Professor of Medicine, 
                                Division of Nephrology
                                    Washington, University in St. Louis
         

        Questions?

        If you have questions about this webinar, please contact Bonnie Freshly, Senior Project Specialist for Excellence in Patient Care, at bfreshly@asn-online.org.

        For more about ASN, and EPC, visit our website at epc.asn-online.org.