ASN represents more than 21,000 kidney health professionals working to help people with kidney diseases and their families. Comprised of all of ASN's focus areas, the ASN Alliance for Kidney Health allows the society to continue its growth and work towards the goal of a world without kidney diseases.
The latest Nephrology Self-Assessment Program (nephSAP) issue, Volume 23: Issue 4 (Oct 2024): Chronic Kidney Disease is now available online.
RE: Steroids dependent nephrotic syndrom 1 minutes ago
I question if "he noticed more foamy urine, slight edema. His ACR was 200mg/" only 200 mg/g of albuminuria would give you foamy urine . I w...
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RE: PGNMID 1 hour ago
Thanks so much for your advice! ------------------------------ Madeline Kirby MD Newport News VA (336) 543-5227 ------------------------------
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RE: drop in bicarb level more after starting emoagliflozin 2 hours ago
One possibility for the proteinuria: A much cheaper and better alternative than finerenone --given the already low HCO3-- would be adding chlorthal...
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RE: drop in bicarb level more after starting emoagliflozin 3 hours ago
Collection time: Nov 26, 2024@12:54 Test Name Result Units Range --------- ------ ----- ----- SODIUM 62 mmol/L POTASSIUM 21.6 mmol/L CH...
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RE: drop in bicarb level more after starting emoagliflozin 4 hours ago
Because of worsened Albuminuria,, Albumin to creatinine ratio rising to 1112 and Urine protein to Creatinine ratio 1. 59 despite being on Empaglifl...
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RE: drop in bicarb level more after starting emoagliflozin 4 hours ago
Type 4 RTA Is another possibility but potassium level has never been elevated and has been 3.7 to 4.7 for years and he is on Lisinopril 15 mg daily...
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RE: drop in bicarb level more after starting emoagliflozin 4 hours ago
Edited from above correcting errors -----White gentleman age 47 with presumed type 2 diabetes that has always been insulin requiring so it is not c...
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drop in bicarb level more after starting emoagliflozin 4 hours ago
White gentleman age 47 with presumed type 2 diabetes that has always been insulin requiring so it is not completely sure whether it is type II, sta...
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Steroids dependent nephrotic syndrom 5 hours ago
Dear colleagues, I have been following a 50-year-old patient with no past medical history of revelance, with nephrotic syndrome minimal change d...
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RE: Steroid dependent FSGS with "tip lesion" 5 hours ago
I would absolutely continue Rituximab, now and probably in 6 months again too! I would also follow his CD 19 cells and if they reconstitute befo...
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RE: symptomatic methemoglobinemia 6 hours ago
I would contact https://www.extrip-workgroup.org extrip.info@gmail.com Even if they cannot help, I am certain they would like to know about ...
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RE: Re: kidney biopsy findings in a young lady 6 hours ago
Good point. I missed the supplemental post. It is not clear (at least to me) if the Paraffin IF with Pronase included staining for kappa and lambda...
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RE: Re: kidney biopsy findings in a young lady 6 hours ago
Dr Fogo has spoken and I would go with her opinion. I do believe therapy can extend the functional life of her kidneys. As for pronase, it seems ...
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RE: symptomatic methemoglobinemia 7 hours ago
Addendum- you are quite correct thar Hydrogen Peroxide contamination can produce a similar effect as chloramine . Have you tested water fir total C...
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RE: symptomatic methemoglobinemia 7 hours ago
Your description is most likely methemoglobinemua from chloramine exposure in improperly prepared dialysate . Search for the origin of chloramine i...
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RE: Hypomagnesemia 7 hours ago
Both the CUBN and PTPRO mutations are present in heterozygous state and should be present in homozygous state/digenic variants to be pathogenic. Th...
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symptomatic methemoglobinemia 8 hours ago
We have couple of adult patients who suffer from symptomatic methemoglobinemia and severe hemolytic anemia requiring blood transfusion . It starts ...
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RE: Hypomagnesemia 9 hours ago
Hi Dr. Glassock, here is the deidentified Natera report. It also showed 2 other mutations, a carrier for CUBN and a VUS of an autosomal recessive m...
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RE: Steroid dependent FSGS with "tip lesion" 17 hours ago
Thank you , Dr Glassock ------------------------------ Rochak Varma MD Oro Valley AZ (917) 459-0750 ------------------------------
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RE: Hypomagnesemia 17 hours ago
I thought that HNF4A mutations were associated with MODY. HNF 1B heterozygous mutations are associated with renal Magnesium wasting, resembling Git...
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RE: Hypomagnesemia 23 hours ago
I've only gotten a patient up to 15 mg bid, but have heard of others who've done more. 100% agree on SGLT2 plan. Laura Maursetter showed this gre...
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RE: Hypomagnesemia 1 day ago
@Joshua Waitzman ------------------------------ Roger Rodby MD, FASN Professor of Medicine Rush University Medical Center Chicago IL (773) ...
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RE: Elevated of B2-microglobulin in dialysis patients 1 day ago
Dr. Rosales. Thanks for the additional information. As noted in comments in thus thread, on-line HDF is not widely available (yet) in the USA and i...
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RE: Hypomagnesemia 1 day ago
Thanks Dr. Rodby. I’ll see if I can convince him on sglt2i I remember Josh Waitzman say in the “Channel your enthusiasm” podcast that he uses high...
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RE: Elevated of B2-microglobulin in dialysis patients 1 day ago
Greetings to everyone. In response to Dr. Glassock and Dr. Rodby's comments about HDF... I think our clinical practice is not necessarily an ex...
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RE: Hypomagnesemia 1 day ago
I assume he never received venetoclax (lymphoma) or cetuximab (head and neck, prostate, and bowel cancer) PPIS do it but they are off and that w...
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RE: Elevated of B2-microglobulin in dialysis patients 1 day ago
This middle molecules are important v middle molecules (MM) are not important, HDF v HD argument has been going on for years. Franky I find it tire...
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Hypomagnesemia 1 day ago
A 67 yr old male with type 2 diabetes developed cramping of his muscles and was found to have a low serum Magnesium of 1.0. He has had several low ...
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RE: Re: kidney biopsy findings in a young lady 1 day ago
Proteinase K works as well as pronase. In the article on MPGN with masked monoclonal depositis. Mayo used pronase and Arkana (Nephropath at the tim...
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RE: Elevated of B2-microglobulin in dialysis patients 1 day ago
Thanks. I agree. The Rosales experience in Chile seems to be an outlier, at least in respect to conventional HD, but maybe it needs more validation...
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RE: primary Membranous nephropathy and HBV infection 1 day ago
In the absence of HBV infection I would treat such a patient without delay,, if Nephrotic Syndrome (NS) was present. With concomitant HBV, I do not...
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RE: Elevated of B2-microglobulin in dialysis patients 1 day ago
B2M level is rarely measured in our practice. Kidney is not the only organ that clears B2M. I think we will be chasing our tail if it is used in al...
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RE: primary Membranous nephropathy and HBV infection 1 day ago
Do you have any threshold of the PLA2R levels by ELISA above which you would recommend immunosuppressive therapy regardless of any other factor? fo...
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RE: Aspergillosis in resistant ANCA associated GN 1 day ago
I think the initial treatment was effective, perhaps a bit too aggressive if anything, which leads me to suspect that this entire 'relapse' could b...
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RE: Steroid dependent FSGS with "tip lesion" 1 day ago
Sparsentan has never been tested for this approach and is not approved by the FDA for this indication. The drug failed to meet its primary end poin...
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RE: Steroid dependent FSGS with "tip lesion" 1 day ago
Is it worth trying Sparsentan to maintain remission after giving Rituximab and tapering Prednisone ? --------------------------------- Rochak Var...
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RE: PIGN with Nephrotic Syndrome case 1 day ago
Prior serologies not available. But i did all of them recently and C3 and C4 not low anymore; SIFE with Faint free lambda light chain noted with no...
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RE: Elevated of B2-microglobulin in dialysis patients 2 days ago
Dr. Rodby-are you aware of any dialysis center in the USA (of course primarily using conventional HD) that monitors Serum B2 microglobulin levels o...
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RE: Re: kidney biopsy findings in a young lady 2 days ago
Thank you. I may elect to repeat the biopsy in that case considering her age and prospects of transplantation ------------------------------ [Sri...
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RE: Re: kidney biopsy findings in a young lady 2 days ago
Thank you Dr Rodby ------------------------------ [Sriram] [Sriperumbuduri] [MBBS FASN] [Assistant Professor in Nephrology] [Virginia Commonwealt...
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RE: Re: kidney biopsy findings in a young lady 2 days ago
Thank you Dr Fogo ------------------------------ [Sriram] [Sriperumbuduri] [MBBS FASN] [Assistant Professor in Nephrology] [Virginia Commonwealth...
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RE: PIGN with Nephrotic Syndrome case 2 days ago
Low C3 and C4 makes this unlikely to be post-streptococcal GN. The therapy of infection-related GN is not steroids and RTX. What is his current C3 ...
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RE: Elevated of B2-microglobulin in dialysis patients 2 days ago
Before the availability of high flux hemofilters we saw a sizable number of dialysis patients affected with carpal tunnel syndrome and sometimes bo...
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PIGN with Nephrotic Syndrome case 2 days ago
I have a 70-year-old male with past medical history of HTN, DM 2, TIA, current smoker started to have LE swelling December 2023. Found to have AKI ...
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RE: Aspergillosis in resistant ANCA associated GN 2 days ago
90 and CYC, prednisolone, avacopan, and rituximab. There is no excuse for the ID lack of help, you really need some really good ID and pulmonary...
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RE: Elevated of B2-microglobulin in dialysis patients 2 days ago
I have no doubt middle molecules are important and the reason HDF is showing less mortality than HD, in more and more reports. However I wonder h...
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RE: Re: kidney biopsy findings in a young lady 2 days ago
nice article explaining the role of Pronase digestion IF, attached 1) regular IF sample not adequate 2) there may be masked monoclonality --...
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RE: Re: kidney biopsy findings in a young lady 2 days ago
As pointed out by Dr. Fogo the sampling for frozen IF is not really adequate for any interpretation. This might be a concealed monoclonal gammopath...
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RE: Elevated of B2-microglobulin in dialysis patients 2 days ago
I cannot imagine a situation where monitoring serum Beta2microglobulin levels in patients on PD for therapy of ESKD as a guide to management decisi...
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RE: Elevated of B2-microglobulin in dialysis patients 2 days ago
Additionally, you can check these articles: Impact change in serum beta microglobulin by combination therapy of peritoneal dialysis and hemodialy...
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