RE: Rituximab for "maintenance " of a CR in PLA2R related MN 3 hours ago

In terms of "what is going on?", FWIW, I (n =1) have taken the PLA2R measurements seriously, based a lot on what I have learned from you guys in th...

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RE: Rituximab for "maintenance " of a CR in PLA2R related MN 7 hours ago

Thanks Dr. Rodby- the question as posted was very specific to PLA2R related MN in a complete clinical and immunological remission (anti-PLA2R antib...

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RE: Rituximab for "maintenance " of a CR in PLA2R related MN 7 hours ago

"Answer to Question posed by Dr Glassock is not really known" Don't you think that is why he asked It? I put my opinion out there, now you have t...

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RE: Patient with LCDD on kidney biopsy but no clone found in the bone marrow 9 hours ago

Was Paraffin iF following Pronase digestion ever done in this case? ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (949...

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RE: Rituximab for "maintenance " of a CR in PLA2R related MN 11 hours ago

Answer to Question posed by Dr Glassock is not really known --------------------------------- Bajinder Reen MD Etobicoke ON (905) 453-0821 -----...

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RE: Rituximab for "maintenance " of a CR in PLA2R related MN 14 hours ago

If the remission was "spontaneous" bc something was done, stopping eg lipoic acid , Hg (Nell1) NSAIAs, treating syphillis, Hepatitis, cancer, etc t...

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RE: What is the etiology 14 hours ago

I would give 2 grams now, separated by two weeks for each gram, assuming that achieved remission and was steroid free, then I would give another si...

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RE: What is the etiology 17 hours ago

Thank You Drs. Rodby and Glassock. What is the duration of Rituximab you recommend? ------------------------------ Asma Qayyum MD West Houston...

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Rituximab for "maintenance " of a CR in PLA2R related MN 19 hours ago

What role , if any , does therapy with RTX play in prevention of relapses following a spontaneous or RTX /CYC induced complete clinical and immunol...

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RE: Comparison of CVVHD vs CVVHF on Dialyzer life span 21 hours ago

Thanks a lot Prof.Teixeira Regards, Yassin ------------------------------ Ahmed Yassin MD, FASN Saudi German Hospital Madina ----------------...

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RE: Diffuse Lymphoid infiltrate on native kidney biopsy w/o lymphoproliferative disorder. 1 day ago

follow up: Seen today in follow up. Her serum creatinine, that peaked at 6 4 weeks ago is now 1.1. ------------------------------ Victor Gur...

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RE: Comparison of CVVHD vs CVVHF on Dialyzer life span 1 day ago

Hey Dr. Yassin -- Very good (and certainly controversial question). As already alluded to in the discussion, if doing CVVH with 100% post-filter re...

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RE: Comparison of CVVHD vs CVVHF on Dialyzer life span 1 day ago

Not to be picky, but I was comparing pure HF (CVVHF) with pure HD (CVVHD) and pure HD would have no "predilution", so I suspect you are talking abo...

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RE: What is the etiology 1 day ago

It is hard to put this all together but it is acting like a very steroid responsive podocytopathy, so responsive that by the time you biopsy the FP...

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RE: What is the etiology 1 day ago

Thank you for your response Dr. Glassock. Please see the attached documents. These are all the reports I have. ------------------------------...

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RE: What is the etiology 1 day ago

Thanks for the correction of the post. I can find no literature supporting a connection of eosinophilic esophagitis and MCD. The elevated IgE level...

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RE: What is the etiology 2 days ago

Thank you for bringing the april report to my attention. please find attached the edited reports. ------------------------------ Asma Qayyum ...

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RE: What is the etiology 2 days ago

Sorry, but the rules require that all identification of patient be redacted before a response can be Made, see the April 2025 Biopsy Report. ----...

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RE: Comparison of CVVHD vs CVVHF on Dialyzer life span 2 days ago

Thanks for reply Predilution decreases dialyzer clotting with both HF and HD modalities. I can conclude that larger molecules with HF have insig...

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What is the etiology 2 days ago

Hello everyone, I need help with a case. 65 white F with PMH of HTN, nephrotic syndrome, HLD, DM - 1c 6.6 (recently diagnosed), asthma, uri...

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What is the etiology 2 days ago

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RE: Complex SLE Case with Diffuse Alveolar Hemorrhage 2 days ago

"I recommend checking CRP, IL-6 , and ferritin levels. If markedly elevated, I would consider administering tocilizumab, while keeping in mind the ...

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RE: Diffuse Lymphoid infiltrate on native kidney biopsy w/o lymphoproliferative disorder. 2 days ago

I would do a chest/abd/pelvic CT to look for lymphadenopathy and splenomegaly. Another option is a PET/CT. You can also do a peripheral blood flow ...

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RE: Complex SLE Case with Diffuse Alveolar Hemorrhage 2 days ago

I would be very cautious about using GSCF in this fulminant inflammatory catasprophe. There is also a major risk of mortality from over Immunosuppr...

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RE: Complex SLE Case with Diffuse Alveolar Hemorrhage 2 days ago

I see, yes eltrombopag is for "ITP" and I dont think you can call this ITP in the setting of SLE. regardless as a thrombopoeitein receptor agon...

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RE: Complex SLE Case with Diffuse Alveolar Hemorrhage 2 days ago

I gave ravulizumab (long-acting complement C5 inhibitor ) last week, presuming there is element of TMA (see the original post) LDH has plateaued ...

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RE: Comparison of CVVHD vs CVVHF on Dialyzer life span 2 days ago

CVVHF hemoconcentrates the blood as it goes through the filter, but ONLY if you give the RF post filter. We always did CVVHF with pre filter RF b...

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RE: Complex SLE Case with Diffuse Alveolar Hemorrhage 2 days ago

I doubt the low WBC is disease activity, more likely the effect of the CYC. plex, steroids, CYC, ravulizumab, Rituximab, and now eltrombopag I'...

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RE: Complex SLE Case with Diffuse Alveolar Hemorrhage 2 days ago

Update Rituximab was given yesterday 20/April The patient remains intubated but the ventilator settings have improved for 2 days now ; however,...

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Comparison of CVVHD vs CVVHF on Dialyzer life span 2 days ago

Dear Respected Is there a considerable difference between impact of the modality of CVVHD and the modality of CVVHF regarding life span or clotti...

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RE: Advanced IgA Nephropathy 2 days ago

Thank you Dr Glassock, that's a great point. Ethan Orlev, MD FACP

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RE: Diffuse Lymphoid infiltrate on native kidney biopsy w/o lymphoproliferative disorder. 2 days ago

We recently saw a 77 y o lady with CLL, CKD III due to DM and HTN that developed AKI and became anuric requiring dialysis. The kidney biopsy can be...

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RE: Advanced IgA Nephropathy 3 days ago

I doubt that Sparsentan would result in harm, but the prospects for meaningful clinical benefit are low and uncertain. If BP became easier to contr...

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RE: Advanced IgA Nephropathy 3 days ago

Hi Dr Hirsch Thank you for your reply! I agree with you. The patient unfortunately is not very compliant. Would you even consider the Sparsentan ?...

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RE: Advanced IgA Nephropathy 3 days ago

If you can get his BP under control his GFR will almost certainly decrease, esp if the ARB is increased, maybe even to 15 or less, depending on how...

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RE: Advanced IgA Nephropathy 3 days ago

With a GFR this low and severe IFTA it is unlikely that any therapy will greatly alter the high likelihood of further progression to ESKD. The tria...

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Advanced IgA Nephropathy 3 days ago

Hi My pt is 38 y/o M who was diagnosed with IgA Nephropathy on 3/2024 pt had a hematuria episode as a child that was treated with steroids an...

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RE: Diffuse Lymphoid infiltrate on native kidney biopsy w/o lymphoproliferative disorder. Saturday, April 19 @ 1:48 PM

Biopsy was done for rapidly rising Cr and proteinuria worsening from around 1 g to 7 g in 6 months before biopsy was done. No h/o pyuria I agree ...

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RE: Diffuse Lymphoid infiltrate on native kidney biopsy w/o lymphoproliferative disorder. Saturday, April 19 @ 1:36 PM

PET/CT was negative. Oncologist has agreed to do BM biopsy ------------------------------ Asjad Sardar MD SOUTHWEST KIDNEY INSTITUTE Tucson AZ (6...

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RE: PIGN with only proteinuria? Friday, April 18 @ 4:24 PM

I think we are all in agreement that glomerular sub-epithelial "hump-like" deposits are non-specific having been observed in APSGN, IRGN, C3GN, DDD...

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RE: PIGN with only proteinuria? Friday, April 18 @ 2:00 PM

In Primary C3GN the "intensity" of C3 staining by conventional IF is required to be greater than the intensity of IgG , IgA or IgM. The serum C3 le...

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RE: Electrolyte Issue Friday, April 18 @ 1:54 PM

Vegetable proteins have a net alkaline content, whereas meat protein has a net acid content, but both proteins stimulate acid (proton) secretion in...

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RE: Volunteer by May 7 to serve as a case report reviewer for Kidney Week 2025! Friday, April 18 @ 1:38 PM

If you are interested serving as a reviewer, please complete this form by May 7: https://www.asn-online.org/apply/?ID=21 Questions? Send an email...

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RE: Volunteer by May 7 to serve as a case report reviewer for Kidney Week 2025! Friday, April 18 @ 1:32 PM

Hi I am a fellow in Pediatric Nephrology. I am willing to volunteer to review case reports Thank you Afsana Jahan Get Outlook for iOS The informa...

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RE: PIGN with only proteinuria? Friday, April 18 @ 12:21 PM

@ prof glassock ? C3 GN would the c3 be more intensity on IF? Or are there cases where c3 is equal intensity to others and it’s is c3gn? I unders...

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RE: Electrolyte Issue Friday, April 18 @ 12:17 PM

Thanks everyone really enlightening . Questions lead to discovery . I apologies for not being clever but why does vegetarian meal give rise to high...

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RE: Electrolyte Issue Friday, April 18 @ 11:29 AM

As a fellow at NYU long ago, my attending Bernie Nidus, showed us his clear, pre-prandial urine, followed by a post-prandial urine: completely opaq...

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RE: PIGN with only proteinuria? Friday, April 18 @ 10:36 AM

Th IF is PLA2R, sorry the label didn't show up. ------------------------------ Jonathan Zuckerman MD, PhD UCLA Los Angeles CA (310) 794-1485 ---...

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RE: PIGN with only proteinuria? Friday, April 18 @ 10:35 AM

I don't disagree that the deposits appear hump-like. Rare cases of early MN can show somewhat humpy deposits. Please see attached images from a cas...

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RE: PIGN with only proteinuria? Friday, April 18 @ 10:12 AM

those are HUMPS! was there only C3 on the biopsy? What was the blood C3 level? See attached ------------------------------ Ro...

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