Abstract: TH-PO826
Performance of GFR Estimating Equations in Kidney Transplant Recipients of Various Races
Session Information
- Transplantation: Clinical - I
November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 2102 Transplantation: Clinical
Authors
- Budhiraja, Pooja, Mayo Clinic Arizona, Scottsdale, Arizona, United States
- Butterfield, Richard J., Mayo Clinic Arizona, Scottsdale, Arizona, United States
- Heilman, Raymond L., Mayo Clinic Arizona, Scottsdale, Arizona, United States
- Hommos, Musab S., Mayo Clinic Arizona, Scottsdale, Arizona, United States
- Me, Hay Me, Mayo Clinic Arizona, Scottsdale, Arizona, United States
- Cheungpasitporn, Wisit, Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Alajous, Salah Bahaa, Mayo Clinic Arizona, Scottsdale, Arizona, United States
- Khurana, Tejas Singh, Mayo Clinic Arizona, Scottsdale, Arizona, United States
- Khamash, Hasan, Mayo Clinic Arizona, Scottsdale, Arizona, United States
Background
We compared the performance of various estimated Glomerular filtration rate (eGFR) equations in kidney transplant recipients of different races.
Methods
This single-center study compares eGFR with measured GFR at 1-year post-transplant.
Results
There were 1145 subjects with 1-year eGFR and mGFR data. Whites made up 54%, followed by Hispanics (23%), Blacks (9%), Native Americans (7%), and Asians (6%). Among Whites, 2021 CKD-EPI creatinine cystatin C-based equations outperformed others [r=0.72, 95% CI (0.65, 0.78)]. The Cockcroft-Gault creatinine equation was the best correlated, least biased, and most accurate (83.7% A30). In Blacks, both 2009 CKD-EPI [ r=0.56, 95% CI (0.42,0.68)] and 2021 CKD-EPI [r=0.56, 95% CI (0.41, 0.68) ] had a weak correlation. The new EKFC (rescaled) cystatin C equation did not perform better in blacks than the 2021 CKD-EPI creatinine or 2012 CKD-EPI cystatin C-based equations. Cockcroft-Gault creatinine equation had the best correlation [ r=0.68, 95% CI (0.56, 0.77)], followed by the 2021 CKD-EPI creatinine-cystatin C equation (0.63, 95% CI (0.43, 0.77). Among Hispanics, cystatin C and combined creatinine cystatin C-based equations were superior, with the 2021 CKD-EPI creatinine-cystatin C equation being the most accurate (84.6%) and highly correlated [r=0.78 (0.69, 0.85)]. In Native Americans, the creatinine-cystatin and EKFC cystatin c equations achieved the highest 30% accuracy (>85%).
Conclusion
The study suggests that combined equations of creatinine-cystatin C performed better than creatinine-based equations and the cystatin C-based equations in all races. EKFC rescaled cystatin equation performed better than 2021 CKD EPI. There was no substantial difference between the 2009 CKD EPI and the new 2021 CKD-EPI equation, which does not factor in race.