Abstract: FR-PO805
Association Between Physical Activity and Cardiovascular Events, Tumors, and All-Cause Mortality in Patients with Maintenance Hemodialysis with Different Nutritional Status
Session Information
- Health Maintenance, Nutrition, Metabolism - II
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Liu, Hongyan, NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Disease, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medicical University, Tianjin, China
- Chen, Yuyang, Tianjin Dongli Hospital, Tianjin, China
- Feng, Tao, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China
- Yu, Pei, NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Disease, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medicical University, Tianjin, China
Background
The current research focuses on the effects of nutritional supplementation and exercise on dialysis patients, but Whether exercise can improve outcomes in patients with different nutritional status is not clear.
Methods
The MHD patients were recruited from April 2021 to April 2022. The information of PA was obtained from the IPAQ and followed up once in 3 months. The outcomes were cardiovascular death, myocardial infarction, stroke, heart failure, atrial fibrillation, tumor, and all-cause death.We used COX proportional risk model to estimate the association between PA and the outcomes of MHD patients.
Patients are classified into two groups based on Geriatric Nutritional Risk Index (GNRI) and classified by age, and we used COX proportional risk model to estimatehe association of PA and outcomes in subgroups. ISM was used to estimate the effects of replacing LPA with MPA or VPA on risk of cardiovascular events, tumors, and all-cause death in different subgroups.The association between PA and outcomes was estimated with COX proportional risk model in different subgroups stratified according to baseline characteristics.The effects of PA on ankle-brachial index and body fat content were analyzed in different IPAQ groups.
Results
A total of 241 maintenance hemodialysis patients were included, 105 peoples developed cardiovascular death, myocardial infarction, stroke, heart failure, atrial fibrillation, tumor or all-cause death(43.6%). The median follow-up time was 12 months. MPA reduced the risk of outocme in MHD patients or high GNRI patients (40%vs39%).In MHD patients who was under 65 years with high GNRI, MPA reduced cardiovascular death, myocardial infarction, stroke, heart failure, atrial fibrillation, tumoror all-cause death by 55%.
PA reduced the risk of cardiovascular event by 65% , but did not reduce the risk of tumor and all-cause death. Replacing LPA with VPA did not improve clinical outcomes.It actually increases the risk of heart failure 0.4%.
Conclusion
MPA reduced the risk of cardiovascular death, myocardial infarction, stroke, heart failure, atrial fibrillation, tumor, or all-cause death in MHD patients under 65 years , while VPA had no health benefit.