Kidney Week

Abstract: TH-PO688

Clinical Characterization and Outcomes of Lupus Nephritis in the Colombian Caribbean: Data from the Lupus Nephritis Register (RENELUP)

Session Information

• Glomerular Diseases: Epidemiology and Case Reports
  November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Glomerular Diseases

• 1402 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

• Aroca Martinez, Gustavo, Universidad Simon Bolivar Facultad de Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Gustavo Aroca Martinez,

• Dominguez-Vargas, Alex, Universidad del Norte Division Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Alex Dominguez-Vargas,

• Gonzalez Torres, Henry J., Universidad Simon Bolivar Facultad de Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Henry J. Gonzalez Torres,

• Musso, Carlos Guido, Universidad Simon Bolivar Facultad de Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Carlos Guido Musso,

• Sanguino, Maria Gabriela, Universidad del Norte Division Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Maria Gabriela Sanguino,

• Velez, Maria De Los Ángeles, Universidad Simon Bolivar Facultad de Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Maria De Los Ángeles Velez,

• Gomez Escorcia, Lorena, Universidad Simon Bolivar Facultad de Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Lorena Gomez Escorcia,

• Palma, Maria F., Universidad Simon Bolivar Facultad de Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Maria F. Palma,

• Roncallo, Camilo José, Clinica de la Costa Ltda, Barranquilla, Atlántico, Colombia

Camilo José Roncallo,

• Sepulveda Ospino, Carlos Jose, Universidad Simon Bolivar Facultad de Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Carlos Jose Sepulveda Ospino,

• Vallejo Patiño, Manuela, Universidad Simon Bolivar Facultad de Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Manuela Vallejo Patiño,

• Orozco, Jesús Alfonso, Universidad Nacional de Colombia Facultad de Medicina, Bogota, Cundinamarca, Colombia

Jesús Alfonso Orozco,

• Ricardo Garcia, Hernando R., Clinica de la Costa Ltda, Barranquilla, Atlántico, Colombia

Hernando R. Ricardo Garcia,

• Barraza, Natalia, Clinica de la Costa Ltda, Barranquilla, Atlántico, Colombia

Natalia Barraza,

• Martinez Bayona, Alvaro A., Universidad Simon Bolivar Facultad de Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Alvaro A. Martinez Bayona,

• Puche Padilla, Jesús David, Universidad Libre - Campus Barranquilla, Barranquilla, Colombia

Jesús David Puche Padilla,

• Egea Bermejo, Eduardo, Universidad del Norte Division Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Eduardo Egea Bermejo,

• Garavito De Egea, Gloria, Universidad del Norte Division Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Gloria Garavito De Egea,

• Navarro Quiroz, Elkin, Universidad Simon Bolivar Facultad de Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Elkin Navarro Quiroz,

• Espitaleta, Zilac, Universidad Simon Bolivar Facultad de Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Zilac Espitaleta,

• Cadena Bonfanti, Andres, Universidad Simon Bolivar Facultad de Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Andres Cadena Bonfanti,

• Fontalvo, Jorge Rico, Universidad Simon Bolivar Facultad de Ciencias de la Salud, Barranquilla, Atlántico, Colombia

Jorge Rico Fontalvo,

Background

LN is a severe manifestation of SLE, impacting outcomes directly and indirectly through therapy. LN varies across populations. Registries are crucial for understanding LN and assessing therapies. This study evaluates LN in RENELUP to assess its status in the Colombian Caribbean.

Methods

A multicenter cohort of 579 LN patients enrolled from 2008 to 2023. RENELUP, a JAVA-based web app, recorded demographic data, severity, outcomes, treatments, and mortality. Patients were grouped into Proliferative (Class III-IV) and Non-Proliferative (Class I-II-V) LN using ISN/RPS criteria. Chi-square/Mann-Whitney U tests evaluated renal survival using Kaplan-Meier estimator.

Results

Most patients were female (87%). Mean age was 41.1±13.1 years. Proliferative LN class IV was the main profile (62%). Proliferative LN had higher serum creatinine, proteinuria, activity index compared to Non-Proliferative LN (p<0.05). Hematuria, chronicity, low C3/C4, and clinical response were similar between LN classes. Overall SLEDAI-2K was 15.4±2.5. MMF (64%) was used as main induction therapy. Renal survival comparable based on serum creatinine at first presentation (p>0.05).

Conclusion

Our study provides insights into LN in the Colombian Caribbean. Predominant proliferative LN Class IV with significant renal involvement was observed. Moderate disease activity and MMF as main induction therapy highlight clinical management in this population, emphasizing the importance of patient registries for monitoring disease and treatment outcomes.