Kidney Week

Abstract: FR-PO848

To Assess Serum Prolactin Levels in Female Patients of CKD on Maintenance Haemodialysis

Session Information

• Women's Health and Kidney Diseases
  November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Women's Health and Kidney Diseases

• 2200 Women's Health and Kidney Diseases

Authors

• Makan, Anuja Pradeep, DY Patil University Deemed to be University School of Medicine, Pune, Maharashtra, India

Anuja Pradeep Makan,

• Dighe, Tushar Anil, DY Patil University Deemed to be University School of Medicine, Pune, Maharashtra, India

Tushar Anil Dighe,

• Bale, Charan Bhadrappa, DY Patil University Deemed to be University School of Medicine, Pune, Maharashtra, India

Charan Bhadrappa Bale,

• Wakhare, Pavan, DY Patil University Deemed to be University School of Medicine, Pune, Maharashtra, India

Pavan Wakhare,

• Shinde, Nilesh, DY Patil University Deemed to be University School of Medicine, Pune, Maharashtra, India

Nilesh Shinde,

• Kulkarni, Akshay Rajiv, DY Patil University Deemed to be University School of Medicine, Pune, Maharashtra, India

Akshay Rajiv Kulkarni,

• Chavan, Abhijit Suresh, DY Patil University Deemed to be University School of Medicine, Pune, Maharashtra, India

Abhijit Suresh Chavan,

• Saha, Debapriya, DY Patil University Deemed to be University School of Medicine, Pune, Maharashtra, India

Debapriya Saha,

• Phadke, Chetan U., DY Patil University Deemed to be University School of Medicine, Pune, Maharashtra, India

Chetan U. Phadke,

• Godbole, Shreeharsh, DY Patil University Deemed to be University School of Medicine, Pune, Maharashtra, India

Shreeharsh Godbole,

• Sajgure, Atul, DY Patil University Deemed to be University School of Medicine, Pune, Maharashtra, India

Atul Sajgure,

Background

Kidneys play an important role in endocrine regulation, not only producing hormones such as erythropoietin and renin but also acting on the metabolism of others such as insulin, cortisol and prolactin. Therefore, CKD patients have numerous endocrine dysfunctions, with changes in feedback loops, reduced transport of protein-bound hormones, and reduced metabolism and hormone elimination.
Hyperprolactinemia occurs by several mechanisms of which reduction in metabolism is one of the main mechanism. The other is increased prolactin secretion by lactotrophs in the uremic state – reduced availability of dopamine in the brain directly stimulates prolactin secretion as also increased autonomic production state.
As a result of hyperprolactinemia, normal cyclic GnRH secretion decreases, resulting in the loss of pulsatile LH and FSH release.
The high elevated level of circulating prolactin in ESRD represents biologically active hormone and is thought to contribute to the high prevalence of hypogonadism, anovulation and sexual dysfunction in patients on dialysis (due to prolactin inhibition of gonadotropin secretion). It is unknown whether higher serum prolactin concentration observed in patients with ESRD are associated with symptoms other than those directly related to relative gonadal deficiency.
Thus, hyperprolactinemia in these patients becomes very prevalent, ranging from 30% in CKD early stages to 65% in those on haemodialysis.

Methods

Observational prospective study with a sample size of 30 patients in the age group of 15 to 45 years

Results

In our study of 30 patients, prolactin was high in 16 patients (53%) of end stage renal disease on dialysis.

Conclusion

To summarise, serum prolactin concentrations were high in a large majority of patients with ESRD.
Even with a greatly increased prevalence in CKD, the clinical diagnosis of hyperprolactinemia in this population is difficult. Signs and symptoms of hyperprolactinemia are confused with some manifestations of CKD itself such as oligomenorrhoea, amenorrhoea, decreased libido, erectile dysfunction, infertility and osteoporosis.