Abstract: SA-PO1077
Characteristics of Renal Allograft Survivors of More than 15 Years: A Single-Center Experience
Session Information
- Transplantation: Clinical - II
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 2102 Transplantation: Clinical
Author
- El Agroudy, Amgad E., Arabian Gulf University, Manama, Bahrain
Background
We studied the characteristics and the predictors of graft and patient survival in Bahraini renal transplant recipients with an allograft that functioned for more than 15 years.
Methods
Out of 185, underwent renal transplantation between 1982 and 2007, 52 patients (28.1%) maintained functioning allografts for more than 15 years (range 15-41 years). Characteristics of the surviving patients, data on graft survival, and determinants of outcome were obtained by reviewing all medical records.
Results
The mean age at time of renal transplantation was 43.1 ± 11.3 years and 75% were males. The cause of end-stage renal disease was diabetic nephropathy in 28.5% and 86% received dialysis therapy before transplantation. The source of the graft in 39 (75%) recipients was from living related donors with a mean age of 31.7 ± 6.6 years, and it was the first graft in 50 recipients. The primary immunosuppression regimen was cyclosporine (CsA) based in 29 patients (29.1%), tacrolimus (Tac) based in 21 patients (40.4%) while three patients (5.6%) received steroids and azathioprine only. Induction therapy was administered to 58 patients. Acute rejection episodes occurred in 10 patients (19.2%), of whom two experienced two episodes. During the last follow-up, the mean serum creatinine was 123 ±36 μmol/L. Two patient were successfully treated for Covid-19 viral infection. A history of hypertension was encountered in 66% and posttransplant diabetes mellitus in 21%. We compared the graft functioning group with the graft failure group and found that the independent determinants of long-term graft survival included age of the recipient, time of late acute rejection episodes, use of induction therapy, histopathologic findings of chronic allograft damage, and serum creatinine at one year.
Conclusion
We conclude that renal transplantation in its earliest years and despite the associated numerous complications has provided a fifteen-year or more of near-normal life to patients with end-stage renal disease.