Abstract: TH-PO206
Role of Dual-Energy Computed Tomography (DECT) in Detection of Carotid Artery Monosodium Urate Deposition (MSU) in Patients with CKD
Session Information
- Hypertension and CVD: Clinical - I
November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1602 Hypertension and CVD: Clinical
Authors
- Sarfraz, Muhammad Danish, The University of British Columbia, Vancouver, British Columbia, Canada
- Treanor, Lee, The University of British Columbia, Vancouver, British Columbia, Canada
- Nicolaou, Savvas, The University of British Columbia, Vancouver, British Columbia, Canada
- Sheikh, Adnan M., The University of British Columbia, Vancouver, British Columbia, Canada
Background
To find out if a Dual energy CT can detect MSU deposition in carotid arteries in patients with CKD and whether the presence of monosodium urate crystals has any effect on atherosclerotic disease in terms of plaque volume.
Methods
This is a retrospective study. All patients with CKD who underwent Dual energy neck imaging (like carotid angiogram, neck soft tissues or cervical spine) from January 2015 to December 2022 were included.
Charts were reviewed to find CKD patients and potential confounding variables like isolated gout or smoking which can add to atherosclerotic disease.
Same number of healthy controls were included which were then age (within 5 years), sex and confounders-matched to CKD patients using MedCalc.
DECT datasets were post-processed using Syngo.ViaVB30 with MSU application and Calcium scoring application for volumetric analysis of atherosclerotic plaque.
Results
Out of total 2157 patients who underwent dual energy neck imaging during study period, 85 were established CKD cases with confirmed clinical and laboratory evidence. Of 85 CKD cases, 2 were excluded due to presence of artefacts from dentures, n=83.
Out of 83, MSU was detected in carotid arteries of 10 patients (12%).
None of the matched control patient demonstrated MSU deposition.
Volumetric analysis of atherosclerotic plaque demonstrated larger plaque volumes in CKD patients with MSU (n=10) than matched CKD patients without MSU (n=10) and matched control/non-CKD patients (n=10) (p value of 0.03).
Conclusion
1. Dual energy CT is an effective tool to detect MSU deposition in carotid arteries of patients with CKD.
2. MSU deposition increases atherosclerosis which can lead to increased TIA/strokes and hence has significant role in patient’s morbidity.